dc.creator | Silva Gallardo, Constanza Paulina | |
dc.creator | Flores Carrasco, Sergio | |
dc.date.accessioned | 2015-10-14T15:46:38Z | |
dc.date.available | 2015-10-14T15:46:38Z | |
dc.date.created | 2015-10-14T15:46:38Z | |
dc.date.issued | 2015 | |
dc.identifier | Rev Med Chile 2015; 143: 707-715 | |
dc.identifier | 0034-9887 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/134362 | |
dc.description.abstract | Background: Alleles involved in inefficient (ADH1B2*2 and ALDH2*2)
or efficient (SNP6, ADH4 gene) alcohol metabolism may influence the risk
of alcoholism. Alcoholism susceptibility has been classified as protector and
risk-dependence phenotypes, associated with inefficient and efficient alcohol
genetic metabolizing variants, respectively. Aim: To investigate the possible
association between genetic protective and risk-dependence variants and alcohol
intake patterns. Material and Methods: Saliva DNA samples were obtained
and the AUDIT (Alcohol Use Disorders Identification Test) questionnaire was
applied to 210 university students aged between 18 and 25 years old. Results: No
statistically significant association between protective or risk-dependence genetic
variants and alcohol pattern intake was detected. However, new categories of
alcohol intake patterns-not included in the AUDIT questionnaire-were identified.
Conclusions: No association between the protector and risk-dependence phenotypes
and patterns of alcohol consumption was detected in this sample of students. | |
dc.language | es | |
dc.publisher | Sociedad Médica de Santiago | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
dc.subject | Alcohol Dehydrogenase | |
dc.subject | Alcohol Drinking | |
dc.subject | Aldehyde Dehydrogenase | |
dc.subject | Genetics | |
dc.subject | Population | |
dc.subject | Genetic Variation | |
dc.title | Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile | |
dc.type | Artículo de revista | |