Artículo de revista
High Levels of Iron Status and Oxidative Stress in Patients with Metabolic Syndrome
Fecha
2013Registro en:
Biol Trace Elem Res (2013) 151:1–8
DOI 10.1007/s12011-012-9525-3
Autor
Leiva, Elba
Mujica, Verónica
Sepúlveda, Pablo
Guzmán, Luis
Núñez, Sergio
Orrego, Roxana
Palomo, Iván
Andrews, Mónica
Arredondo Olguín, Miguel Armando
Institución
Resumen
Studies concerning oxidative stress (OxE) parameters
have increased, mainly because of its important role in
cardiovascular diseases and diabetes complications. The
main objective of this study was to evaluate iron nutrition
status and oxidative stress parameters in subjects that had
developed metabolic syndrome (MetS). Subjects from the
Research Program of Risk Factors for Cardiovascular Disease
(n0155) were studied (ages ranging from 45 to 65 years
old) and classified according to the Adult Treatment Panel
III criterion. A blood sample was taken after a 12-h fasting
period, and basal glucose, insulin, thiobarbituric acid reactive
substances (TBARS), oxidized LDL (oxLDL), heme
oxygenase (HO) activity, lipid profile, and iron nutrition
status were determined. Eighty-five subjects were classified
as MetS, and 70 non-MetS. Individuals with MetS showed
higher Fe storage (high levels of ferritin, total body iron and
low transferrin receptor), oxLDL, TBARS, and homeostatic
model assessment for insulin resistance levels. The MetS
group showed high levels of oxidative stress parameters
(HO activity, oxLDL, and TBARS). The presence of MetS
showed an association with LDL oxidation risk (multiple
lineal regression according to sex and age, p<0.001). High
levels of triglycerides (p<0.001) and waist circumference (p
<0.012) were associated with oxLDL levels, as well as an
association between TBARS and oxLDL with ferritin levels.
Through logistic regression analyses, the highest quartile of
ferritin was associated with a threefold risk of developing
MetS compared to the lowest quartile; also, TBARS showed
a 21-fold risk for the development of MetS. Finally, elevated
levels of oxidative stress parameters such us oxLDL,
TBARS, HO, and Fe storage were associated to MetS.