Artículos de revistas
Analyses by GC-MS and GC-MS-MS of the hantzsch synthesis products using hydroxy- and methoxy-aromatic aldehydes
Fecha
2007-05-09Registro en:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 44(1):236-242
0731-7085
Autor
Núñez Vergara, Luis
Navarrete Encina, Patricio
Salas, S.
Conde, B.
Carbajo, J.
Squella Serrano, Juan
Camargo Grandón, Rodrigo
Institución
Resumen
El mass spectra of products of the dihydropyridine Hantzsch synthesis using hydroxy and methoxy aldehydes as starting materials are reported. The reaction products (C-4 hydroxy- and methoxyphenyl-1,4-dihydropyridines and chromeno[3,4,c]-pyridines) were derivatized with N-methyl-N-(trimethylsilyl)-trifluoracetamide to be analyzed by gas chromatographic techniques. Fragmentation pathways for 1,4-dihydropyridines and chromeno-pyridines are proposed. The study provides (mainly through MS-MS technique) useful data for the confirmation of the structure of the compounds and also is a valuable tool for further analytical purposes to follow both photostability and reactivity studies with free radicals for these types of compounds.