Artículo de revista
Synthesis and Dopamine Receptor Selectivity of the Benzyltetrahydroisoquinoline, (R)-(+)-nor-Roefractine
Fecha
1998-01-15Registro en:
Journal of Natural Products, Vol. 61, No. 6, 1998.
0163-3864
Autor
Cabedo, Nuria
Protais, Philippe
Cassels Niven, Bruce
Cortes, Diego
Institución
Resumen
(R)-(+)-nor-Roefractine (1) was synthesized
by the Bischler-Napieralski route, using asymmetric
reduction of the 1,2-didehydro precursor imine with
sodium (S)-N-CBZ-prolinyloxyborohydride. Compound
1 was able to displace [3H]-raclopride (a D2 dopamine
receptor-selective ligand) from its specific binding sites
in rat striatum with selectivity vs [3H]-SCH23390 (D1
dopamine receptor-selective ligand).