Antifungal Activity of Saponin-rich Extracts of Phytolacca dioica and of the Sapogenins Obtained through Hydrolysis

dc.creatorLiberto, Melina Di
dc.creatorSvetaz, Laura
dc.creatorFurlán, Ricardo L. E.
dc.creatorZacchino, Susana
dc.creatorDelporte Vergara, Carla
dc.creatorNovoa, Marco A.
dc.creatorAsencio, Marcelo
dc.creatorCassels Niven, Bruce
dc.date.accessioned2012-05-18T15:03:02Z
dc.date.accessioned2019-04-25T23:22:07Z
dc.date.available2012-05-18T15:03:02Z
dc.date.available2019-04-25T23:22:07Z
dc.date.created2012-05-18T15:03:02Z
dc.date.issued2010-05-20
dc.identifierNPC Natural Product Communications, vol. 5, nº 7, p.993-1160, 2010
dc.identifier1555-9475
dc.identifierhttp://repositorio.uchile.cl/handle/2250/119398
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2423755
dc.description.abstractA saponin-rich extract of Phytolacca dioica L. berries, its acid hydrolysate, and its major aglycone, phytolaccagenin, were assayed for antifungal activity against ATCC standard cultures of Candida albicans and Cryptococcus neoformans, and against clinical isolates of these fungi. The activity of the extract was either low or negligible, but the hydrolysate, containing the sapogenins, including phytolaccagenin, and also pure phytolaccagenin, showed promising antifungal potency. Hydrolysis of a natural product extract is shown to be a useful modification leading to improved bioactivity.
dc.languageen
dc.publisherEDITORIAL BOARD
dc.subjectSaponins
dc.titleAntifungal Activity of Saponin-rich Extracts of Phytolacca dioica and of the Sapogenins Obtained through Hydrolysis
dc.typeArtículos de revistas


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