Prevalencia de enfermedad celiaca en Latinoamérica: revisión sistemática de la literatura y meta-análisis
Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Because information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the word through a systematic review and meta-analysis Methods and Findings: This report describes a two-phase study. First, a cross-sectional analysis from 300 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were made following the PRISMA guidelines. Our results disclose a lack of anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA) autoantibody in Colombians. In the systematic review, after 72 studies that met the selection criteria were considered, the estimated prevalence of CD in LA was 0,46% to 0,64%, whereas the prevalence of CD was 5,5 to 5,6% in first degree relatives of CD patients and 4,6% to 8,7% in type 1 diabetes mellitus patients. Conclusions: Our study shows that prevalence of CD in healthy patients from LA is similar to the prevalence reported in the European population.