masterThesis
Incidencia de síndrome de abstinencia secundario a opioides y/o benzodiacepinas en dos unidades de cuidados intensivos pediátricos
Fecha
2017Autor
Ríos Gálvez, Blanca Isabel
Alvarado, Manuel
Institución
Resumen
Introduction: Withdrawal syndrome (WS) is the set of symptoms and signs that occur when abruptly stops the administration of a drug once physical dependence has been established.
•Objective: To characterize patients with secondary WS to opioids and / or benzodiazepines during hospitalization in the pediatric intensive care Clínica Infantil Colsubsidio (CIC) and the Hospital del Niño in Panama (HDN) from 1 April to 30 September 2016.
• Materials and Methods: This was a descriptive, longitudinal, prospective study. We included 189 patients in the CIC and 144 patients in the HDN. The SOPHIA scale was used for the diagnosing of withdrawal; the COMFORT scales for evaluating sedation in unrelaxed ventilated patients and the FLACC scale for evaluating analgesia. The StataV12® software was used for statistical analysis.
• Results: A global incidence rate of WS of 6.1 / 100 days people was reported. The cumulative incidence of WS was 56.08% and 29.86% for the CIC and HDN respectively. At the CIC in the 69.81% of patients who required infusion of opioids and benzodiazepines developed WS. Acumulative dose of fentanyl of 530.34 ± 276.49 mcg / kg was reported. At the HDN, 53.49% of the patients who received opioids and benzodiazepines developed the syndrome.
Conclusion: WS secondary to opioids and / or benzodiazepines is frequent in our intensive care units with a variable incidence, and a higher frequency of WS with the use of both medications, higher cumulative doses and more days of continuous infusion.