masterThesis
Evaluación de la variabilidad del tiempo de duración de la relajación neuromuscular del cisatracurium vs rocuronio en pacientes ancianos
Fecha
2010Registro en:
TEME 0003 2010
Autor
Jaller Bornacelli, Yamil Elías
Montes Romero, Felix Ramón
Institución
Resumen
Objective: To compare the variability in the clinically effective duration of action (defined as the time of appearance of T125% to stimulation by train of four) and recovery of neuromuscular function after the administration of a bolus of 3 ED95 to ED95 of cisatracurium or 2 rocuronium in patients over 65 years undergoing surgery.
Materials and Methods: Were included for this estuudio patients over 65 years of both sexes scheduled for elective surgery requiring general anesthesia, who during preanesthetic evaluation should be included within the classification of ASA 1, 2 or 3. Patients need having signed the anesthetic consent , and not to impaired renal function, history of hepatic dysfunction, cardiovascular disease uncompensated neurological or neuromuscular disease, acid-base imbalance, or being under treatment with drugs that interact with the relaxants. Patients were randomized using a permuted block method in two groups: Group 1: Muscle relaxation with cisatracurium 0.15 mg / kg IV and Group 2: muscle relaxation with rocuronium 0.6 mg / kg IV. We included 68 patients to whom he was quantified by using the TOF-Watch SX device payable are the times: T0, T125%, T4/T1 and T4/T1 = 80% = 90%. Based on these measurements were obtained measures of central tendency and dispersion, subsequently conducted an analysis of variance and / or tests not depending on the distribution parameter to determine the variability between the times obtained in each group.
Results: The groups were comparable in terms of age, sex, number of patients (p> 0.05). The result was final that cisatracurium is less variable than rocuronium for each of the variables T0, T125%, T4/T1 and T4/T1 = 80% = 90% (p <0.01) in elderly patients taken to surgery more 90 minutes requiring neuromuscular relaxation.
Conclusion: Cisatracurium is less variable than when using rocuronium in elderly patients undergoing major surgery that requires 90 minutes of neuromuscular relaxation and can be a drug cisatracurium more predictable in their time of action, thus the probability associated with effects on residual neuromuscular relaxation is smaller.