Relationship between α7 nAChR and apoptosis in human lymphocytes

dc.creatorde Rosa, Maria Jose
dc.creatorEsandi, María del Carmen
dc.creatorGarelli, Andres
dc.creatorRayes, Diego Hernán
dc.creatorBouzat, Cecilia Beatriz
dc.date.accessioned2018-05-02T15:25:22Z
dc.date.available2018-05-02T15:25:22Z
dc.date.created2018-05-02T15:25:22Z
dc.date.issued2005-03
dc.identifierde Rosa, Maria Jose; Esandi, María del Carmen; Garelli, Andres; Rayes, Diego Hernán; Bouzat, Cecilia Beatriz; Relationship between α7 nAChR and apoptosis in human lymphocytes; Elsevier Science; Journal of Neuroimmunology; 160; 1-2; 3-2005; 154-161
dc.identifier0165-5728
dc.identifierhttp://hdl.handle.net/11336/43844
dc.identifierCONICET Digital
dc.identifierCONICET
dc.description.abstractThe presence of nicotinic receptors (nAChRs) in blood cells has been demonstrated. However, little is known about their functional roles. We have detected mRNA of a7 nAChR in peripheral human lymphocytes and determined that its expression is highly variable among individuals and within the same individual at different times. Upregulation of a7 is systematically observed after incubation of lymphocytes with nicotine or a-bungarotoxin. In addition, the incubation with these drugs decreases the percentage of apoptotic cells induced by the exposure to cortisol. Our results suggest that a7 nAChRs are involved in the modulation of cortisol-induced apoptosis.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165572804004382
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jneuroim.2004.11.010
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAPOPTOSIS
dc.subjectLYMPHOCYTE
dc.subjectNICOTINE
dc.subjectΑ7 NICOTINIC RECEPTOR
dc.titleRelationship between α7 nAChR and apoptosis in human lymphocytes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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