Artículos de revistas
Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones
Faccone, Diego Francisco; Lopez Ruitti, Paula; Vazquez, Miryam; Guerriero, Leonor; Lucero, Celeste; et al.; Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones; Elsevier Science; Infection, Genetics and Evolution; 44; 10-2016; 507-509
Faccone, Diego Francisco
Lopez Ruitti, Paula
Gagetti, Paula Silvana
We report an H. parainfluenzae clinical isolate resistant to cefotaxime and with decreased susceptibility to ciprofloxacinrecovered from a patient with cystic fibrosis. The isolate had elevated MICs of ampicillin (256 mg/L), amoxicillin-clavulanate(8 mg/L), cefuroxime (8 mg/L) and cefotaxime (4 mg/L), and showed a β-lactamase-producing amoxicillin-clavulanicacid-resistant (BLPACR) phenotype. A blaTEM-1 plus five amino acid substitutions in the PBP3 were found:Ser385Thr, Val511Ala, Ile519Val, Asn526Lys and Asp551Leu. MIC of ciprofloxacin was 0.5 mg/L, and substitutions ingyrA (Ser84Tyr) and parC (Ser84Phe) genes were detected.