Electrochemical Behavior of Verapamil at Graphite-Polyurethane Composite Electrodes: Determination of Release Profiles in Pharmaceutical Samples

dc.creatorSEMAAN, Felipe S.
dc.creatorCAVALHEIRO, Eder T. G.
dc.creatorBRETT, Christopher M. A.
dc.date.accessioned2012-10-20T05:34:17Z
dc.date.accessioned2018-07-04T15:52:05Z
dc.date.available2012-10-20T05:34:17Z
dc.date.available2018-07-04T15:52:05Z
dc.date.created2012-10-20T05:34:17Z
dc.date.issued2009
dc.identifierANALYTICAL LETTERS, v.42, n.8, p.1119-1135, 2009
dc.identifier0003-2719
dc.identifierhttp://producao.usp.br/handle/BDPI/31864
dc.identifier10.1080/00032710902890470
dc.identifierhttp://dx.doi.org/10.1080/00032710902890470
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1628502
dc.description.abstractA solid graphite-polyurethane composite electrode has been used to determine release profiles of verapamil, a calcium-channel blocker. The electro-oxidation process was characterized by cyclic voltammetry and electrochemical impedance spectroscopy and showed no adsorption of analyte or oxidation products, unlike at other carbon-based electrodes. Quantification gave linear ranges up to 40molL-1 with cyclic voltammetry and detection limits of 0.7molL-1 by differential pulse and square-wave voltammetry. Commercial product samples were successfully analyzed with results equal to those from spectrophotometry. Because no electrode surface renewal is needed, this electrode material has many advantages.
dc.languageeng
dc.publisherTAYLOR & FRANCIS INC
dc.relationAnalytical Letters
dc.rightsCopyright TAYLOR & FRANCIS INC
dc.rightsrestrictedAccess
dc.subjectComposite electrode
dc.subjectrelease profile
dc.subjectverapamil
dc.titleElectrochemical Behavior of Verapamil at Graphite-Polyurethane Composite Electrodes: Determination of Release Profiles in Pharmaceutical Samples
dc.typeArtículos de revistas


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