Stability and compatibility study on enalapril maleate using thermoanalytical techniques

dc.creatorREZENDE, R. L. O.
dc.creatorSANTORO, M. I. R. M.
dc.creatorMATOS, J. R.
dc.date.accessioned2012-10-20T05:23:47Z
dc.date.accessioned2018-07-04T15:49:32Z
dc.date.available2012-10-20T05:23:47Z
dc.date.available2018-07-04T15:49:32Z
dc.date.created2012-10-20T05:23:47Z
dc.date.issued2008
dc.identifierJOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v.93, n.3, p.881-886, 2008
dc.identifier1388-6150
dc.identifierhttp://producao.usp.br/handle/BDPI/31274
dc.identifier10.1007/s10973-007-8187-4
dc.identifierhttp://dx.doi.org/10.1007/s10973-007-8187-4
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1627912
dc.description.abstractThis paper demonstrates the application of thermal analysis in compatibility and stability studies between it ACE inhibitor (enalapril maleate) and excipients. The results have helped to elucidate the reason of a stability problem observed (luring the storage of enalapril maleate tablets. Incompatibility between enalapril maleate and colloidal silicon dioxide was detected. Besides, it was confirmed that the reaction between enalapril maleate and NaHCO3 increases the thermal stability of the drug. This Study Supports the importance of using thermoanalytical methods in the development of pharmaceuticals.
dc.languageeng
dc.publisherSPRINGER
dc.relationJournal of Thermal Analysis and Calorimetry
dc.rightsCopyright SPRINGER
dc.rightsrestrictedAccess
dc.subjectcompatibility
dc.subjectDSC
dc.subjectenalapril maleate
dc.subjectstability
dc.subjectTG
dc.subjectthermal stabilization
dc.titleStability and compatibility study on enalapril maleate using thermoanalytical techniques
dc.typeArtículos de revistas


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