dc.creator | SANTORO, Maria Ines Rocha Miritello | |
dc.creator | TSUBONE, Camila | |
dc.creator | GOMES, Fabio Pereira | |
dc.creator | KEDOR-HACKMANN, Erika Rosa Maria | |
dc.creator | GARCIA, Pedro Lopez | |
dc.date.accessioned | 2012-10-19T03:19:16Z | |
dc.date.accessioned | 2018-07-04T14:56:59Z | |
dc.date.available | 2012-10-19T03:19:16Z | |
dc.date.available | 2018-07-04T14:56:59Z | |
dc.date.created | 2012-10-19T03:19:16Z | |
dc.date.issued | 2008 | |
dc.identifier | ANALYTICAL LETTERS, v.41, n.11, p.2044-2057, 2008 | |
dc.identifier | 0003-2719 | |
dc.identifier | http://producao.usp.br/handle/BDPI/19901 | |
dc.identifier | 10.1080/00032710802209342 | |
dc.identifier | http://dx.doi.org/10.1080/00032710802209342 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1616686 | |
dc.description.abstract | High performance liquid chromatographic (HPLC) and UV derivative spectrophotometric (UVDS) methods were developed and validated for the quantitative determination of sotalol hydrochloride in tablets. The HPLC method was performed on a C18 column with fluorescence detection. The excitation and emission wavelengths were 235 and 310nm, respectively. The mobile phase was composed of acetonitrile-water containing 0.1% trietylamine (7:93v/v) and pH adjusted to 4.6 with formic acid. The UVDS method was performed taking a signal at 239.1nm in the first derivative. The correlation coefficients (r) obtained were 0.9998 and 0.9997 for HPLC and UVDS methods, respectively. The proposed methods are simple and adaptable to routine analysis. | |
dc.language | eng | |
dc.publisher | TAYLOR & FRANCIS INC | |
dc.relation | Analytical Letters | |
dc.rights | Copyright TAYLOR & FRANCIS INC | |
dc.rights | restrictedAccess | |
dc.subject | beta-blockers | |
dc.subject | high performance liquid chromatography | |
dc.subject | pharmaceutical formulations | |
dc.subject | sotalol hydrochloride | |
dc.subject | UV derivative spectrophotometry | |
dc.title | Development and validation of high performance liquid chromatographic and UV-derivative spectrophotometric methods for the determination of sotalol hydrochloride in tablets | |
dc.type | Artículos de revistas | |