Circulating Concentrations Of Adipocytokines And Their Receptors In The Isolate Corpus Cvernosum And Femoral Artery From Trained Rats On A High-fat Diet

dc.creatorSponton
dc.creatorAmanda C. S.; Silva
dc.creatorFabio H.; Araujo
dc.creatorHygor N.; da Silva
dc.creatorCarmem P. Valgas; de Moraes
dc.creatorCamila; Antunes
dc.creatorEdson; Zanesco
dc.creatorAngelina; Delbin
dc.creatorMaria A.
dc.date2017
dc.date2017-11-13T13:13:23Z
dc.date2017-11-13T13:13:23Z
dc.date.accessioned2018-03-29T05:51:21Z
dc.date.available2018-03-29T05:51:21Z
dc.identifierJournal Of Vascular Research. Karger, v. 54, p. 33 - 50, 2017.
dc.identifier1018-1172
dc.identifier1423-0135
dc.identifierWOS:000399173100004
dc.identifier10.1159/000457800
dc.identifierhttps://www.karger.com/Article/Abstract/457800
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327038
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364063
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. Methods: Functional experiments were performed in control sedentary and trained rats, and sedentary (h-SD) and trained male Wistar rats on a high-fat diet (h-TR). Nitric oxide (NO) and reactive oxygen species (ROS) were evaluated in vascular tissue. Circulating adipocytokines and their receptors were analyzed. Results: In the h-SD group, the maximal responses to acetylcholine (ACh) were reduced in the femoral artery and corpus cavernosum as well as the electrical field stimulation, accompanied by an increase in circulating insulin, leptin, TNF-alpha, MCP-1, and PAI-1. Downregulation of ObR protein expression in the femoral artery was observed without alterations in AdipoR1 and TNFR1 in both prepara-tions. A positive effect was observed in the h-TR group regarding the relaxation response to ACh and circulating adipocytokines, resulting in increased NO production and reduced ROS generation. Exercise restored the ObR protein expression only in the femoral artery. Conclusion: Aerobic exercise training ameliorated the inflammatory adipocytokines and restored the relaxation responses in the corpus cavernosum and femoral artery in rats on a high-fat diet. (C) 2017 S. Karger AG, Basel
dc.description54
dc.description1
dc.description33
dc.description50
dc.descriptionCNPq [441514/2014-6]
dc.descriptionFAPESP [2013/26886-4]
dc.descriptionPEMBERTON Coca-Cola Brasil
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherKarger
dc.publisherBasel
dc.relationJournal of Vascular Research
dc.rightsfechado
dc.sourceWOS
dc.subjectCorpus Cavernosum
dc.subjectFemoral Artery
dc.subjectAerobic Exercise
dc.subjectAdipocytokines
dc.subjectHigh-fat Diet
dc.subjectEndothelial Dysfunction
dc.titleCirculating Concentrations Of Adipocytokines And Their Receptors In The Isolate Corpus Cvernosum And Femoral Artery From Trained Rats On A High-fat Diet
dc.typeArtículos de revistas


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