Phenotypic Characteristics Of Resistant Hypertension In The Brazilian Population.

dc.creatorFaria, Ana Paula Cabral de
dc.creatorSabbatini, Andréa Rodrigues
dc.creatorCoca, Antonio
dc.creatorMoreno, Heitor
dc.date2013-Jun
dc.date2015-11-27T13:31:43Z
dc.date2015-11-27T13:31:43Z
dc.date.accessioned2018-03-29T01:17:45Z
dc.date.available2018-03-29T01:17:45Z
dc.identifierArquivos Brasileiros De Cardiologia. v. 100, n. 6, p. 579-82, 2013-Jun.
dc.identifier1678-4170
dc.identifier10.5935/abc.20130100
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23657267
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200625
dc.identifier23657267
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300858
dc.descriptionResistant hypertension (RH) is defined as blood pressure that remains above target in spite of the concurrent use of three or more classes of antihypertensive drugs at optimized doses (UCRH), with one of them being a diuretic. Moreover, patients whose blood pressure is controlled while using four or more antihypertensive medications are also considered controlled resistant hypertensive (CRH) subjects. Although this definition may be useful in terms of categorizing a larger group of resistant hypertensive individuals, as these two subgroups share high cardiovascular risk, some important clinical and pathophysiologic particularities need to be better evaluated, before considering resistant controlled and uncontrolled patients as part of the same group. We compared cardiovascular characteristics of these two subgroups with resistant hypertension. In spite of some similar features, the UCRH subgroup has cardiovascular phenotypes with worse prognosis, such as increased vascular stiffness and left ventricular hypertrophy, as well as more impaired endothelial function and lower nocturnal blood pressure dipping, among others. Considering these differences, the UCRH subgroup is associated with greater cardiovascular risk and may be considered as more resistant to antihypertensive treatment. In addition to the importance of better prevention and treatment of resistant hypertension by identifying early risk factors and optimizing drug therapy, some clinical implications must be considered when managing controlled and uncontrolled patients as similar to the resistant hypertension group.
dc.description100
dc.description579-82
dc.languageeng
dc.languagepor
dc.relationArquivos Brasileiros De Cardiologia
dc.relationArq. Bras. Cardiol.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAntihypertensive Agents
dc.subjectBlood Pressure
dc.subjectBrazil
dc.subjectCardiovascular Diseases
dc.subjectDrug Resistance
dc.subjectDrug Therapy, Combination
dc.subjectHumans
dc.subjectHypertension
dc.subjectPhenotype
dc.subjectPrognosis
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.titlePhenotypic Characteristics Of Resistant Hypertension In The Brazilian Population.
dc.typeArtículos de revistas


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