Endothelial Dysfunction In Cardiovascular And Endocrine-metabolic Diseases: An Update.

dc.creatorDavel, A P
dc.creatorWenceslau, C F
dc.creatorAkamine, E H
dc.creatorXavier, F E
dc.creatorCouto, G K
dc.creatorOliveira, H T
dc.creatorRossoni, L V
dc.date2011-Sep
dc.date2015-11-27T13:21:54Z
dc.date2015-11-27T13:21:54Z
dc.date.accessioned2018-03-29T01:13:57Z
dc.date.available2018-03-29T01:13:57Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 44, n. 9, p. 920-32, 2011-Sep.
dc.identifier1414-431X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21956535
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199639
dc.identifier21956535
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299872
dc.descriptionThe endothelium plays a vital role in maintaining circulatory homeostasis by the release of relaxing and contracting factors. Any change in this balance may result in a process known as endothelial dysfunction that leads to impaired control of vascular tone and contributes to the pathogenesis of some cardiovascular and endocrine/metabolic diseases. Reduced endothelium-derived nitric oxide (NO) bioavailability and increased production of thromboxane A2, prostaglandin H2 and superoxide anion in conductance and resistance arteries are commonly associated with endothelial dysfunction in hypertensive, diabetic and obese animals, resulting in reduced endothelium-dependent vasodilatation and in increased vasoconstrictor responses. In addition, recent studies have demonstrated the role of enhanced overactivation of β-adrenergic receptors inducing vascular cytokine production and endothelial NO synthase (eNOS) uncoupling that seem to be the mechanisms underlying endothelial dysfunction in hypertension, heart failure and in endocrine-metabolic disorders. However, some adaptive mechanisms can occur in the initial stages of hypertension, such as increased NO production by eNOS. The present review focuses on the role of NO bioavailability, eNOS uncoupling, cyclooxygenase-derived products and pro-inflammatory factors on the endothelial dysfunction that occurs in hypertension, sympathetic hyperactivity, diabetes mellitus, and obesity. These are cardiovascular and endocrine-metabolic diseases of high incidence and mortality around the world, especially in developing countries and endothelial dysfunction contributes to triggering, maintenance and worsening of these pathological situations.
dc.description44
dc.description920-32
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCardiovascular Diseases
dc.subjectDiabetes Mellitus
dc.subjectEndocrine System Diseases
dc.subjectEndothelium, Vascular
dc.subjectEndothelium-dependent Relaxing Factors
dc.subjectHumans
dc.subjectMetabolic Diseases
dc.subjectNitric Oxide
dc.subjectNitric Oxide Synthase Type Iii
dc.subjectObesity
dc.subjectRats
dc.titleEndothelial Dysfunction In Cardiovascular And Endocrine-metabolic Diseases: An Update.
dc.typeArtículos de revistas


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