No Association Of The 5' Promoter Region Polymorphism Of Cyp17 Gene With Prostate Cancer Risk.

dc.creatordos Santos, A
dc.creatorRibeiro, M L
dc.creatorMesquita, J C
dc.creatorCarvalho-Salles, A B
dc.creatorHackel, C
dc.date2002
dc.date2015-11-27T12:49:30Z
dc.date2015-11-27T12:49:30Z
dc.date.accessioned2018-03-29T00:56:58Z
dc.date.available2018-03-29T00:56:58Z
dc.identifierProstate Cancer And Prostatic Diseases. v. 5, n. 1, p. 28-31, 2002.
dc.identifier1365-7852
dc.identifier10.1038/sj.pcan.4500550
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15195127
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195264
dc.identifier15195127
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295497
dc.descriptionCYP17 gene encodes the enzyme cytochrome p450c17alpha, which mediates two steps in the steroid biosynthesis pathway. Steroid hormones are believed to play a key role in the etiology of prostate cancer. A polymorphic T-->C transition in the 5(') promoter region of CYP17 creates an additional Sp1-type (CCACC box) promoter site (allele A2). We have evaluated the genotypic and allelic distribution of this polymorphism among 92 prostate cancer patients in order to assess risk by comparison with a population-based series of 200 healthy individuals from Brazil. Our results provide no evidence for an association between prostate cancer risk and CYP17 T/C polymorphism.
dc.description5
dc.description28-31
dc.languageeng
dc.relationProstate Cancer And Prostatic Diseases
dc.relationProstate Cancer Prostatic Dis.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectBrazil
dc.subjectCase-control Studies
dc.subjectGene Frequency
dc.subjectGenetic Predisposition To Disease
dc.subjectGenotype
dc.subjectHumans
dc.subjectMale
dc.subjectPolymerase Chain Reaction
dc.subjectPolymorphism, Genetic
dc.subjectPolymorphism, Restriction Fragment Length
dc.subjectPromoter Regions, Genetic
dc.subjectProstate
dc.subjectProstatic Neoplasms
dc.subjectRisk Factors
dc.subjectSteroid 17-alpha-hydroxylase
dc.titleNo Association Of The 5' Promoter Region Polymorphism Of Cyp17 Gene With Prostate Cancer Risk.
dc.typeArtículos de revistas


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