Family-based Association Of Hla Class Ii Alleles And Haplotypes With Type I Diabetes In Brazilians Reveals Some Characteristics Of A Highly Diversified Population.

dc.creatorVolpini, W M
dc.creatorTesta, G V
dc.creatorMarques, S B
dc.creatorAlves, L I
dc.creatorSilva, M E
dc.creatorDib, S A
dc.creatorGuerra, G
dc.creatorPaulino, M F
dc.creatorMarini, S H
dc.creatorPersoli, L B
dc.creatorCaillat-Zucman, S
dc.date2001-Nov
dc.date2015-11-27T12:29:03Z
dc.date2015-11-27T12:29:03Z
dc.date.accessioned2018-03-29T00:55:30Z
dc.date.available2018-03-29T00:55:30Z
dc.identifierHuman Immunology. v. 62, n. 11, p. 1226-33, 2001-Nov.
dc.identifier0198-8859
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11704284
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194881
dc.identifier11704284
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295114
dc.descriptionThe association of HLA class II haplotypes with type I diabetes was analyzed in 56 Southeastern Brazilian families using affected family-based controls (AFBAC) method. DRB1-DQA1-DQB1 alleles were determined by polymerase chain reaction/sequence-specific primer genotyping. This study first revealed the great haplotype diversity of Brazilians (65 different haplotypes even with incomplete DRB1 subtyping), probably due to the admixture of Africans genes with European and Amerindian genes in this population. The results revealed increased frequencies of the DRB1*03-DQA1*0501-DQB1*02 and DRB1*0401-DQA1*03-DQB1*0302 haplotypes in the patient group The highest risk for type I diabetes was associated with the heterozygote DRB1*03/*04 genotype as largely reported, and DRB1*03/X and DRB1*04/Y genotypes conferred a significant, but much lower disease risk. Protection from type I diabetes revealed some peculiarities in Southeastern Brazilians: a lack of significant protecting effect of the DRB1*1501-DQA1*0102-DQB1*0602 haplotype, and an apparent protection conferred by the DRB1*13-DQB1*0301, DRB1*11-DQB1*0301, and DRB1*01-DQB1*0501 two-locus haplotypes. The risk to type I diabetes in the highly diversified Southeastern Brazilians evidenced specific information to the prediction of the disease in this region of the country.
dc.description62
dc.description1226-33
dc.languageeng
dc.relationHuman Immunology
dc.relationHum. Immunol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAlleles
dc.subjectBrazil
dc.subjectChild
dc.subjectDiabetes Mellitus, Type 1
dc.subjectFemale
dc.subjectGenes, Mhc Class Ii
dc.subjectGenotype
dc.subjectHla-dq Antigens
dc.subjectHla-dq Alpha-chains
dc.subjectHla-dq Beta-chains
dc.subjectHla-dr Antigens
dc.subjectHla-drb1 Chains
dc.subjectHaplotypes
dc.subjectHumans
dc.subjectMale
dc.titleFamily-based Association Of Hla Class Ii Alleles And Haplotypes With Type I Diabetes In Brazilians Reveals Some Characteristics Of A Highly Diversified Population.
dc.typeArtículos de revistas


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