Increased Insulin Circulating Levels Induced By Canatoxin In Rats.

dc.creatorRibeiro-DaSilva, G
dc.creatorPrado, J F
dc.date1993-Sep
dc.date2015-11-27T12:18:21Z
dc.date2015-11-27T12:18:21Z
dc.date.accessioned2018-03-29T00:50:59Z
dc.date.available2018-03-29T00:50:59Z
dc.identifierToxicon : Official Journal Of The International Society On Toxinology. v. 31, n. 9, p. 1131-6, 1993-Sep.
dc.identifier0041-0101
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/8266345
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193711
dc.identifier8266345
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293944
dc.descriptionCanatoxin, a proteic neurotoxin from Canavalia ensiformis seeds, raises circulating insulin levels and induces hypoglycemia in rats. The hyperinsulinemia produced by canatoxin (6 micrograms kg-1, 20 min; 108% of increase in female rats) was both time and dose dependent and lasted only about 30 min, while the fall in blood glucose levels (around 30%) was long lasting. The hyperinsulinemic response to canatoxin was greater in females (+108 +/- 18%) than males (+43 +/- 8%), but no difference was noted in the hypoglycemia. Pretreatment of rats with either naloxone, naltrexone, atropine or hexamethonium abolished both the hyperinsulinemia and the hypoglycemia. These data suggest that these phenomena are influenced by opioids and depend on parasympathetic stimulation.
dc.description31
dc.description1131-6
dc.languageeng
dc.relationToxicon : Official Journal Of The International Society On Toxinology
dc.relationToxicon
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectEndorphins
dc.subjectFemale
dc.subjectHypoglycemia
dc.subjectInsulin
dc.subjectLectins
dc.subjectMale
dc.subjectNarcotic Antagonists
dc.subjectNeurotoxins
dc.subjectParasympathetic Nervous System
dc.subjectParasympathomimetics
dc.subjectPlant Proteins
dc.subjectRadioimmunoassay
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSex Characteristics
dc.subjectStimulation, Chemical
dc.subjectToxins, Biological
dc.titleIncreased Insulin Circulating Levels Induced By Canatoxin In Rats.
dc.typeArtículos de revistas


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