Mutations In The P53 Gene In Acute Myeloid Leukemia Patients Correlate With Poor Prognosis

dc.creatorMelo M.B.
dc.creatorAhmad N.N.
dc.creatorLima C.S.P.
dc.creatorPagnano K.B.B.
dc.creatorBordin S.
dc.creatorLorand-Metze I.
dc.creatorSaad S.T.O.
dc.creatorCosta F.F.
dc.date2002
dc.date2015-06-30T16:42:41Z
dc.date2015-11-26T15:33:26Z
dc.date2015-06-30T16:42:41Z
dc.date2015-11-26T15:33:26Z
dc.date.accessioned2018-03-28T22:41:59Z
dc.date.available2018-03-28T22:41:59Z
dc.identifier
dc.identifierHematology. , v. 7, n. 1, p. 13 - 19, 2002.
dc.identifier10245332
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0036290536&partnerID=40&md5=00ce01d6795cfb8a4d4f57b7e592956c
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/101689
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/101689
dc.identifier2-s2.0-0036290536
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1262744
dc.descriptionInactivation of tumor suppressor genes, whose products exert an inhibitory influence on cell cycle progression, can lead to neoplastic transformation. In acute myeloid leukemia (AML), the frequency of p53 gene mutations ranges from 4 to 15% in populations from USA and Europe. In an attempt to investigate the frequency of point mutations in the p53 gene in AML Brazilian patients, DNA samples of 35 patients were studied using PCR-SSCP techniques, screening exons 4-10. Mutations were identified in bone marrow DNA in 5 of the 35 AML patients (14.3%), a frequency similar to those reported for Northern American and European populations. The overall survival of patients with mutations in the p53 gene was significantly shorter than for patients without mutations.
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dc.descriptionDiamandis, E.P., "Clinical applications of the p53 tumor suppressor gene" (1995) Clinica Chimica Acta, 237, pp. 79-90
dc.descriptionLee, J.M., Bernstein, A., "Apoptosis, cancer and the p53 tumour suppressor gene" (1995) Cancer and Methastasis Reviews, 14, pp. 149-161
dc.descriptionFung, C.Y., Fisher, D.E., "p53: From molecular mechanisms to prognosis in cancer" (1995) Journal of Clinical Oncology, 13, pp. 808-811
dc.descriptionLane, D.P., Crawford, L.V., "T antigen is bound to a host protein in SV40-transformed cells" (1979) Nature, 278, p. 261
dc.descriptionProkocimer, M., Rotter, V., "Structure and function of p53 in normal cells and their aberrations in cancer cells: Projection on the hematologic cell lineages" (1994) Blood, 84, pp. 2391-2411
dc.descriptionKuerbitz, S.J., Plunkett, B.S., Walsh, W.V., Kastan, M.B., "Wild-type p53 is a cell cycle checkpoint determinant following irradiation" (1992) Proceedings of the National Academy of Sciences of the USA, 89, pp. 7491-7495
dc.descriptionKastan, M.B., Onyekwere, O., Sidransky, D., Vogelstein, B., Craig, R.W., "Participation of p53 protein in the cellular response to DNA damage" (1991) Cancer Research, 51, pp. 6304-6311
dc.descriptionHollstein, M., Sidransky, D., Vogelstein, B., Harris, C.C., "p53 mutations in human cancers" (1991) Science, 253, pp. 49-53
dc.descriptionBosari, S., Viale, G., "The clinical significance of p53 aberrations in human tumours" (1995) Virchows Archives, 427, pp. 229-241
dc.descriptionVelculescu, V.E., El-Deiry, W.S., "Biological and clinical importance of the p53 tumor suppressor gene" (1996) Clinical Chemistry, 42, pp. 858-868
dc.descriptionImamura, J., Miyoshi, I., Koeffler, P., "p53 in hematologic malignancies" (1994) Blood, 84, pp. 2412-2421
dc.descriptionGuinn, B., Padua, R.A., "Do p53 mutations have a role in the initiation and progression of leukemia?" (1997) Cancer Journal, 8, pp. 1-9
dc.descriptionFenaux, P., Preudhomme, C., Quiquandon, I., Jonveaux, P., Laï, J.L., Vanrumbeke, M., Loucheux-Lefebvre, M.H., Kerckaert, J.P., "Mutations of the p53 gene in acute myeloid leukemia" (1992) British Journal of Haematology, 80, pp. 178-183
dc.descriptionHu, G., Zhang, W., Deisseroth, A.B., "p53 gene mutations in acute myelogenous leukaemia" (1992) British Journal of Haematology, 81, pp. 489-494
dc.descriptionKurosawa, M., Okabe, M., Kunieda, Y., Asaka, M., "Analysis of the p53 gene mutations in acute myelogenous leukemia" The p53 gene mutations associated with a deletion of chromosome 17" (1995) Annals of Hematology, 71, pp. 83-87
dc.descriptionWattel, E., Preudhomme, C., Hecquet, B., Vanrumbeke, M., Quesnel, B., Dervite, I., Morel, P., Fenaux, P., "p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies" (1994) Blood, 84, pp. 3148-3157
dc.descriptionNakano, Y., Kiyoi, H., Miyawaki, S., Asou, N., Ohno, R., Saito, H., Naoe, T., (1999) British Journal of Haematology, 104, pp. 659-664
dc.descriptionNakano, Y., Naoe, T., Kiyoi, H., Kitamura, K., Minami, S., Miyawaki, S., Asou, N., Ohno, R., "Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia" (2000) European Journal of Haematology, 65, pp. 23-31
dc.descriptionSeliger, B., Papadileris, S., Vogel, D., Hess, D., Brendel, C., Storkel, S., Ortel, J., Neubauer, A., "Analysis of the p53 and MDM-2 gene in acute myeloid leukemia" (1996) European Journal of Haematology, 57, pp. 230-240
dc.descriptionLorand, I.G.H., Souza, C.A., Costa, F.F., "Hematological toxicity associated with agricultural chemicals" (1984) Lancet, 1, p. 404
dc.descriptionBennett, J.M., Catovsky, D., Daniel, M.-T., Flandrin, G., Galton, D.A.G., Gralnick, H.R., Sultan, C., "Proposals for classification of the acute leukaemias: French-American-British (FAB) Cooperative Group" (1976) British Journal of Haematology, 33, pp. 451-458
dc.descriptionBennett, J.M., Catovsky, D., Daniel, M.-T., Flandrin, G., Galton, D.A.G., Gralnick, H.R., Sultan, C., "Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7): A report of the French-American-British Cooperative Group" (1985) Annals of Internal Medicine, 103, pp. 460-462
dc.descriptionBennett, J.M., Catovsky, D., Daniel, M.-T., Flandrin, G., Galton, D.A.G., Gralnick, H.R., Sultan, C., "Proposed revised criteria for the classification of acute myeloid leukemia: A report of the French-American-British Cooperative Group" (1985) Annals of Internal Medicine, 103, pp. 626-629
dc.descriptionYunis, J.J., "New chromosome techniques in the study of human neoplasia" (1981) Human Pathology, 12, pp. 540-549
dc.descriptionTesta, J.R., Rowley, J.D., "Chromosomes in leukemia and lymphoma with special emphasis on methodology" (1980) The Leukemia Cell, p. 184. , Catovsky, D., ed, (Churchill-Livingstone, Edinburg)
dc.descriptionMitelman, F., (1991), ISNC: Guidelines for Cancer Cytogenetics, Supplement to an International System for Human Cytogenetic Nomenclature (Karger, Basel)Büchner, T., Hiddemann, W., Loffler, G., Gassmann, W., Maschmeyer, G., Heit, W., Hossfeld, D., Heinecke, A., "Improved cure rate by very early intensification combined with prolonged maintenance chemotherapy in patients with acute myeloid leukemia: Data from the AML Cooperative Group" (1991) Seminars in Hematology, 28 (3 SUPPL. 4), pp. 76-79
dc.descriptionWahlin, A., Hörnsten, P., Jonsson, H., "Remission rate and survival in acute myeloid leukemia: Impact of selection and chemotherapy" (1991) European Journal of Haematology, 46, pp. 240-247
dc.descriptionSambrook, J., Fritsch, E.F., Maniatis, T., (1989) Molecular Cloning, a Laboratory Manual, , 2nd ed. (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY)
dc.descriptionSaiki, R.K., Gelfand, D.H., Stoffel, S., Scharf, S.J., Higushi, R., Horn, G.T., Mullis, K.B., Erlich, H.A., "Primer-directed enzymatic amplification of DNA with thermostable DNA polymerase" (1988) Science, 239, pp. 487-491
dc.descriptionOrita, M., Iwahana, H., Kanazawa, H., Hayashi, K., Sekiya, T., "Detection of polymorphisms of human DNA by gel electrophoresis as single-strand coformation-polymorphisms" (1989) Proceedings of the National Academy of Sciences of the USA, 86, pp. 2766-2770
dc.descriptionMohabeer, A.J., Hiti, A.L., Martin, W.J., "Non-radioactive single strand conformation polymorphism (SSCP) using the Pharmacia "PhastSystem" (1991) Nucleic Acids Research, 19, p. 3154
dc.descriptionConover, W.J., (1971) Practical Nonparametric Statistics, , (Wiley, New York)
dc.descriptionCollett, D., (1994) Modelling Survival Data in Medical Research, , (Chapman & Hall, Londres)
dc.descriptionTrecca, D., Longo, L., Biondi, A., Cro, L., Calori, R., Grignani, F., Maiolo, A.T., Neri, A., "Analysis of p53 gene mutations in acute myeloid leukemia" (1994) American Journal of Hematology, 46, pp. 304-309
dc.descriptionBühler-Leclerc, M., Gratwohl, A., Senn, H., "Occurrence of point mutations in p53 gene is not increased in patients with acute myeloid leukaemia carrying an activating N-ras mutation" (1993) British Journal of Haematology, 84, pp. 443-450
dc.descriptionDicciani, M.B., Yu, J., Hsiao, M., Mukherjee, S., Shao, L.-E., Yu, A.L., "Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia" (1994) Blood, 84, pp. 3105-3112
dc.descriptionPreudhomme, C., Dervite, I., Wattel, E., Vanrumbeke, M., Flactif, M., Lai, J.C., Hecquet, B., Fenaux, P., "Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: A report of 48 cases" (1995) Journal of Clinical Oncology, 13, pp. 812-820
dc.descriptionLiang, Y.-Y., Esteve, A., Martel-Planche, G., Takahashi, S., Lu, S.-H., Montesano, R., Hollstein, M., "p53 mutations in esophageal tumors from high-incidence areas of China" (1995) International Journal of Cancer, 61, pp. 611-614
dc.descriptionBhatia, K., Gutiérrez, M.I., Huppi, K., Magrath, I.T., "PCR detection of a neutral CGA/CGG dimorphism in exon 6 of the human p53 gene" (1992) Nucleic Acids Research, 20, p. 928
dc.descriptionChang, Y.-S., Lin, Y.-J., Tsai, C.-N., Shu, C.-H., Tsai, M.-S., Choo, K.-B., Liu, S.-T., "Detection of mutations in the p53 gene in human head and neck carcinomas by single strand conformation polymorphism analysis" (1992) Cancer Letters, 67, pp. 167-174
dc.descriptionFenaux, P., Jonveaux, P., Quiquandon, I., Lai, J.L., Pignon, J.M., Loucheaux-Lefebvre, M.H., Bauters, F., Kerckaert, J.P., "p53 gene mutations in acute myeloid leukemia with 17p monosomy" (1991) Blood, 78, pp. 1652-1657
dc.descriptionNakai, H., Misawa, S., Tanaka, S., Nishigaki, H., Taniwaki, M., Yokota, S., Horiike, S., Kashima, K., "p53 gene mutations and loss of a chromosome 17p in Philadelphia chromosome (Ph 1)-positive acute leukemia" (1993) Leukemia, 7, pp. 1547-1551
dc.descriptionMisawa, S., Horiike, S., Kaneko, H., Sasai, Y., Ueda, Y., Nakao, M., Yokota, S., Kashima, K., "Significance of chromosomal alterations and mutations of the N-ras and TP53 genes in relation to leukemogenesis of acute myeloid leukemia" (1998) Leukemia Research, 22, pp. 631-637
dc.descriptionBuchman, V.J., Chumakov, P.M., Ninkina, N.N., Samarina, O.P., Georgiev, G.P., "A variation in the structure of the protein-coding region of the human p53 gene" (1988) Gene, 70, pp. 245-252
dc.descriptionPignon, J.M., Vinatier, I., Fanen, P., Jonveaux, P., Tournilhac, O., Imbert, M., Rochant, H., Goossens, M., "Exhaustive analysis of the p53 gene coding sequence by denaturing gradient gel electrophoresis: Application to the detection of point mutations in acute leukemias" (1994) Human Mutation, 3, pp. 126-132
dc.descriptionHussain, S.P., Harris, C., "p53 mutation spectrum and load: The generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer" (1999) Mutation Research, 428, pp. 23-32
dc.descriptionKocialkowski, S., Pezzella, F., Morrison, H., Jones, M., Laha, S., Harris, A.L., Mason, D.Y., Gatter, K.C., "Mutations in the p53 gene are not limited to classic hot spots and are not predictive of p53 protein expression in high-grade non-Hodgkin's lymphoma" (1995) British Journal of Haematology, 89, pp. 55-60
dc.descriptionNishida, N., Fukuda, Y., Kokuryu, H., Toguchida, J., Yandell, D.W., Ikenega, M., Imura, H., Ishizaki, K., "Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma" (1993) Cancer Research, 53, pp. 368-372
dc.descriptionChi, S.-G., White, W.V., Meyers, F.J., Siders, D.B., Lee, F., Gumerlock, P.H., "p53 in prostate cancer: Frequent expressed transition mutations" (1994) Journal of the National Cancer Institute, 86, pp. 926-933
dc.descriptionTanaka, H., Shibagaki, I., Shimada, Y., Wagata, T., Imamura, M., Ishizaki, K., "Characterization of p53 gene mutations in esophageal squamous cell carcinoma cell lines: Increased frequency and different spectrum of mutations from primary tumors" (1996) International Journal of Cancer, 65, pp. 372-376
dc.descriptionLane, D.P., "p53 and human cancers" (1994) British Medical Bulletin, 50, pp. 582-599
dc.descriptionCasey, G., Lopez, M.E., Ramos, J.C., Plummer, S.J., Arboleda, M.J., Shaughnessy, M., Karlan, B., Slamon, D.J., "DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies" (1996) Oncogene, 13, pp. 1971-1981
dc.descriptionCiesielski, D., Dziewulska-Bokiniek, A., Zoltoeska, A., Roszkiewicz, A., Kopacz, A., Wojtacki, J., "p53 expression in breast cancer related to prognostic factors" (1995) Neoplasma, 42, pp. 235-237
dc.descriptionField, J.K., Spandidos, D.A., Malliri, A., Gosney, J.R., Yiagnisis, M., Stell, P.M., "Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck" (1991) British Journal of Cancer, 64, pp. 573-577
dc.descriptionOhue, M., Tomita, N., Monden, T., Fujita, M., Fukunaga, M., Takami, K., Yana, I., Mori, T., "A frequent alteration of the p53 gene in carcinoma in adenoma of colon" (1994) Cancer Research, 54, pp. 4798-4804
dc.descriptionKusser, W.C., Miao, X., Glickman, B.W., Friedland, J., Rothman, N., Hemstreet, G.P., Mellot, J., Hayes, R.B., "p53 mutations in human bladder cancer" (1994) Environmental and Molecular Mutation, 24, pp. 156-160
dc.languageen
dc.publisher
dc.relationHematology
dc.rightsfechado
dc.sourceScopus
dc.titleMutations In The P53 Gene In Acute Myeloid Leukemia Patients Correlate With Poor Prognosis
dc.typeArtículos de revistas


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