Effects Of N-3 And N-6 Fatty Acids On The Expression Of Genes Involved In The Lipid Metabolism And Risk Of Atherosclerosis [efeito Dos ácidos Graxos N-3 E N-6 Na Expressão De Genes Do Metabolismo De Lipídeos E Risco De Aterosclerose]

dc.creatorRaposo H.F.
dc.date2010
dc.date2015-06-26T12:37:35Z
dc.date2015-11-26T15:27:18Z
dc.date2015-06-26T12:37:35Z
dc.date2015-11-26T15:27:18Z
dc.date.accessioned2018-03-28T22:36:00Z
dc.date.available2018-03-28T22:36:00Z
dc.identifier
dc.identifierRevista De Nutricao. , v. 23, n. 5, p. 871 - 879, 2010.
dc.identifier14155273
dc.identifier10.1590/S1415-52732010000500017
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79953092688&partnerID=40&md5=3f9f011b09ba57b4704769a1aa00d3e9
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/91210
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/91210
dc.identifier2-s2.0-79953092688
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1261321
dc.descriptionAtherosclerosis, the main cause of myocardial infarction, stroke, gangrene and other peripheral vascular diseases, also persists as the main cause of morbidity and mortality in Western populations. Roughly 17.5 million people died from cardiovascular diseases in 2005, representing 30% of the causes of death in that year, and in 2015, another 20 million people will die of cardiovascular diseases around the world. The n-3 fatty acids, especially the long-chain n-3 found in fish, have been shown to be particularly effective in the prevention and treatment of diseases such as dyslipidemias, diabetes mellitus and obesity, presenting an important cardioprotective effect. In this context, studies have found that at least some of the cardiovascular benefits associated with eicosapentaenoic and docosahexaenoic fatty acids regard the modulation of genes that respond to the peroxisome proliferator-activated receptors involved in lipid metabolism. This review will discuss some of the mechanisms of action of some n-3 and n-6 fatty acids on the metabolism of lipids and lipoproteins. In conclusion, many aspects that contribute to the risk of cardiovascular diseases are affected by n-3 intake. N-3 fatty acids not only reduce triglycerides, but also promote factors that increase adiponectin, reduce blood cholesterol levels and improve the reverse cholesterol transport, and all of these contribute to reducing the risk of atherosclerosis. However, additional studies are still necessary to elucidate all the cellular and molecular mechanisms responsible for the cardioprotective effect of n-3 fatty acids.
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dc.relationRevista de Nutricao
dc.rightsaberto
dc.sourceScopus
dc.titleEffects Of N-3 And N-6 Fatty Acids On The Expression Of Genes Involved In The Lipid Metabolism And Risk Of Atherosclerosis [efeito Dos ácidos Graxos N-3 E N-6 Na Expressão De Genes Do Metabolismo De Lipídeos E Risco De Aterosclerose]
dc.typeArtículos de revistas


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