Brazilian Avian Metapneumovirus Subtypes A And B: Experimental Infection Of Broilers And Evaluation Of Vaccine Efficacy

dc.creatordos Santos M.B.
dc.creatorMartini M.C.
dc.creatorFerreira H.L.
dc.creatorda Silva L.H.
dc.creatorFellipe P.A.
dc.creatorSpilki F.R.
dc.creatorArns C.W.
dc.date2012
dc.date2015-06-25T20:25:24Z
dc.date2015-11-26T15:21:39Z
dc.date2015-06-25T20:25:24Z
dc.date2015-11-26T15:21:39Z
dc.date.accessioned2018-03-28T22:31:06Z
dc.date.available2018-03-28T22:31:06Z
dc.identifier
dc.identifierPesquisa Veterinaria Brasileira. , v. 32, n. 12, p. 1257 - 1262, 2012.
dc.identifier0100736X
dc.identifier10.1590/S0100-736X2012001200008
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84874796105&partnerID=40&md5=c2805d3e23d14dd406dc66732500810c
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90453
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90453
dc.identifier2-s2.0-84874796105
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260258
dc.descriptionAvian metapneumovirus (aMPV) is a respiratory pathogen associated with the swollen head syndrome (SHS) in chickens. In Brazil, live aMPV vaccines are currently used, but subtypes A and, mainly subtype B (aMPV/A and aMPV/B) are still circulating. This study was conducted to characterize two Brazilian aMPV isolates (A and B subtypes) of chicken origin. A challenge trial to explore the replication ability of the Brazilian subtypes A and B in chickens was performed. Subsequently, virological protection provided from an aMPV/B vaccine against the same isolates was analyzed. Upon challenge experiment, it was shown by virus isolation and real time PCR that aMPV/B could be detected longer and in higher amounts than aMPV/A. For the protection study, 18 one-day-old chicks were vaccinated and challenged at 21 days of age. Using virus isolation and real time PCR, no aMPV/A was detected in the vaccinated chickens, whereas one vaccinated chicken challenged with the aMPV/B isolate was positive. The results showed that aMPV/B vaccine provided a complete heterologous virological protection, although homologous protection was not complete in one chicken. Although only one aMPV/B positive chicken was detected after homologous vaccination, replication in vaccinated animals might allow the emergence of escape mutants.
dc.description32
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dc.languageen
dc.publisher
dc.relationPesquisa Veterinaria Brasileira
dc.rightsaberto
dc.sourceScopus
dc.titleBrazilian Avian Metapneumovirus Subtypes A And B: Experimental Infection Of Broilers And Evaluation Of Vaccine Efficacy
dc.typeArtículos de revistas


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