Obesity And Thyroid Cancer

dc.creatorMarcello M.A.
dc.creatorCunha L.L.
dc.creatorBatista F.A.
dc.creatorWard L.S.
dc.date2014
dc.date2015-06-25T17:59:56Z
dc.date2015-11-26T15:01:11Z
dc.date2015-06-25T17:59:56Z
dc.date2015-11-26T15:01:11Z
dc.date.accessioned2018-03-28T22:12:16Z
dc.date.available2018-03-28T22:12:16Z
dc.identifierEndocrine-related Cancer. , v. 21, n. 5, p. T255 - T271, 2014.
dc.identifier10.1530/ERC-14-0070
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84907561119&partnerID=40&md5=d39a2a38c1c033c4a3ff8bc6d1e415f2
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87373
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87373
dc.identifier2-s2.0-84907561119
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256248
dc.descriptionMany studies have provided observational data on the association of obesity and thyroid cancers, but only few of them propose mechanisms that would permit a better understanding of the causal molecular mechanisms of this association. Considering that there is an increasing incidence of both obesity and thyroid cancers, we need to summarize and link recent studies in order to characterize and understand the contribution of obesity-related factors that might affect thyroid cancer development and progression. Adipose tissue is involved in many vital processes, including insulin sensitivity, angiogenesis, regulation of energy balance, activation of the complement system, and responses such as inflammation. Although these processes have their own molecular pathways, they involve the same molecules through which obesity and adipose tissue might exert their roles in carcinogenesis, not only affecting MAPK and PI3K or even insulin pathways, but also recruiting local inflammatory responses that could result in disease formation and progression. This review describes five important issues that might explain the link between excessive weight and thyroid cancer: thyroid hormones, insulin resistance, adipokines, inflammation, and sexual hormones.
dc.description21
dc.description5
dc.descriptionT255
dc.descriptionT271
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dc.relationEndocrine-Related Cancer
dc.rightsfechado
dc.sourceScopus
dc.titleObesity And Thyroid Cancer
dc.typeArtículos de revistas


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