Melatonin Reduces Lh, 17 Beta-estradiol And Induces Differential Regulation Of Sex Steroid Receptors In Reproductive Tissues During Rat Ovulation

dc.creatorA Chuffa L.G.
dc.creatorSeiva F.R.F.
dc.creatorFavaro W.J.
dc.creatorTeixeira G.R.
dc.creatorAmorim J.P.A.
dc.creatorMendes L.O.
dc.creatorFioruci B.A.
dc.creatorPinheiro P.F.F.
dc.creatorFernandes A.A.H.
dc.creatorFranci J.A.A.
dc.creatorDelella F.K.
dc.creatorMartinez M.
dc.creatorMartinez F.E.
dc.date2011
dc.date2015-06-30T20:46:40Z
dc.date2015-11-26T14:55:07Z
dc.date2015-06-30T20:46:40Z
dc.date2015-11-26T14:55:07Z
dc.date.accessioned2018-03-28T22:07:12Z
dc.date.available2018-03-28T22:07:12Z
dc.identifier
dc.identifierReproductive Biology And Endocrinology. , v. 9, n. , p. - , 2011.
dc.identifier14777827
dc.identifier10.1186/1477-7827-9-108
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79960889533&partnerID=40&md5=cde5d0309d793bbff811802001c0f33c
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/109188
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/109188
dc.identifier2-s2.0-79960889533
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1255304
dc.descriptionBackground: Melatonin is associated with direct or indirect actions upon female reproductive function. However, its effects on sex hormones and steroid receptors during ovulation are not clearly defined. This study aimed to verify whether exposure to long-term melatonin is able to cause reproductive hormonal disturbances as well as their role on sex steroid receptors in the rat ovary, oviduct and uterus during ovulation.Methods: Twenty-four adult Wistar rats, 60 days old (+/- 250 g) were randomly divided into two groups. Control group (Co): received 0.9% NaCl 0.3 mL + 95% ethanol 0.04 mL as vehicle; Melatonin-treated group (MEL): received vehicle + melatonin [100 μg/100 g BW/day] both intraperitoneally during 60 days. All animals were euthanized by decapitation during the morning estrus at 4 a.m.Results: Melatonin significantly reduced the plasma levels of LH and 17 beta-estradiol, while urinary 6-sulfatoximelatonin (STM) was increased at the morning estrus. In addition, melatonin promoted differential regulation of the estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) and melatonin receptor (MTR) along the reproductive tissues. In ovary, melatonin induced a down-regulation of ER-alpha and PRB levels. Conversely, it was observed that PRA and MT1R were up-regulated. In oviduct, AR and ER-alpha levels were down-regulated, in contrast to high expression of both PRA and PRB. Finally, the ER-beta and PRB levels were down-regulated in uterus tissue and only MT1R was up-regulated.Conclusions: We suggest that melatonin partially suppress the hypothalamus-pituitary-ovarian axis, in addition, it induces differential regulation of sex steroid receptors in the ovary, oviduct and uterus during ovulation. © 2011 A Chuffa et al; licensee BioMed Central Ltd.
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dc.languageen
dc.publisher
dc.relationReproductive Biology and Endocrinology
dc.rightsaberto
dc.sourceScopus
dc.titleMelatonin Reduces Lh, 17 Beta-estradiol And Induces Differential Regulation Of Sex Steroid Receptors In Reproductive Tissues During Rat Ovulation
dc.typeArtículos de revistas


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