The Contribution Of Hypertension To Diabetic Nephropathy And Retinopathy: The Role Of Inflammation And Oxidative Stress

dc.creatorDe Faria J.B.L.
dc.creatorSilva K.C.
dc.creatorLopes De Faria J.M.
dc.date2011
dc.date2015-06-30T20:29:11Z
dc.date2015-11-26T14:50:27Z
dc.date2015-06-30T20:29:11Z
dc.date2015-11-26T14:50:27Z
dc.date.accessioned2018-03-28T22:01:40Z
dc.date.available2018-03-28T22:01:40Z
dc.identifier
dc.identifierHypertension Research. , v. 34, n. 4, p. 413 - 422, 2011.
dc.identifier
dc.identifier10.1038/hr.2010.263
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79953728467&partnerID=40&md5=ac8d6774ef9e9ca87770086aac9d1e48
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/108113
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/108113
dc.identifier
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1254158
dc.descriptionDiabetes and hypertension frequently coexist and constitute the most notorious combination for the pathogenesis of diabetic nephropathy and retinopathy. Large clinical trials have clearly demonstrated that tight control of glycemia and/or blood pressure significantly reduces the incidence and progression of diabetic retinopathy (DR) and nephropathy. However, the mechanism by which hypertension interacts with diabetes to induce and/or exacerbate nephropathy and retinopathy is very unclear. Substantial evidence implicates the involvement of chronic inflammation and oxidative stress in the pathogenesis of DR and nephropathy. In addition, hypertension causes oxidative stress and inflammation in the kidney and retina. In the present review, we summarized data obtained from our research along with those from other groups to better understand the role of hypertension in the pathogenesis of diabetic nephropathy and retinopathy. It is suggested that oxidative stress and inflammation may be common denominators of kidney and retinal damage in the concomitant presence of diabetes and hypertension. © 2011 The Japanese Society of Hypertension All rights reserved.
dc.description34
dc.description4
dc.description413
dc.description422
dc.descriptionNational High Blood Pressure Education Program Working Group report on hypertension in diabetes (1994) Hypertension, 23, pp. 145-158. , Anonymous
dc.descriptionGeiss, L.S., Rolka, D.B., Engelgau, M.M., Elevated blood pressure among U.S. adults with diabetes, 1988-1994 (2002) American Journal of Preventive Medicine, 22 (1), pp. 42-48. , DOI 10.1016/S0749-3797(01)00399-3, PII S0749379701003993
dc.descriptionJensen, T., Borch-Johnsen, K., Deckert, T., Changes in blood pressure and renal function in patients with type I (insulin-dependent) diabetes mellitus prior to clinical diabetic nephropathy (1987) Diabetes Research, 4 (4), pp. 159-162
dc.descriptionParving, H.H., Controlling hypertension in diabetes (2002) Acta Diabetol, 39, pp. S35-S40
dc.descriptionTarnow, L., Rossing, P., Gall, M.-A., Nielsen, F.S., Parving, H.-H., Prevalence of arterial hypertension in diabetic patients before and after the JNC-V (1994) Diabetes Care, 17 (11), pp. 1247-1251
dc.descriptionStratton, I.M., Cull, C.A., Adler, A.I., Matthews, D.R., Neil, H.A.W., Holman, R.R., Additive effects of glycaemia and blood pressure exposure on risk of complications in type 2 diabetes: A prospective observational study (UKPDS 75) (2006) Diabetologia, 49 (8), pp. 1761-1769. , DOI 10.1007/s00125-006-0297-1
dc.descriptionTight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38 (1998) BMJ, 317, pp. 703-713. , The UKPDS Study Group UK Prospective Diabetes Study Group
dc.descriptionZoungas, S., De Galan, B.E., Ninomiya, T., Grobbee, D., Hamet, P., Heller, S., MacMahon, S., Travert, F., Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial (2009) Diabetes Care, 32, pp. 2068-2074. , ADVANCE Collaborative Group
dc.descriptionGiunti, S., Barit, D., Cooper, M.E., Mechanisms of diabetic nephropathy: Role of hypertension (2006) Hypertension, 48 (4), pp. 519-526. , DOI 10.1161/01.HYP.0000240331.32352.0c, PII 0000426820061000000001
dc.descriptionSchrier, R.W., Estacio, R.O., Esler, A., Mehler, P., Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes (2002) Kidney International, 61 (3), pp. 1086-1097. , DOI 10.1046/j.1523-1755.2002.00213.x
dc.descriptionThomas, M.C., Atkins, R.C., Blood pressure lowering for the prevention and treatment of diabetic kidney disease (2006) Drugs, 66 (17), pp. 2213-2234. , http://drugs.adisonline.com/pt/re/drugs/pdfhandler.00003495-200666170- 00005.pdf;jsessionid=F1dGGhWzy9FYfgqm4hSkJ1rpXyhL5sRFrTvryFMQw0qFK3pQQsmH!- 565972194!-949856144!8091!-1, DOI 10.2165/00003495-200666170-00005
dc.descriptionKlein, R., Knudtson, M.D., Lee, K.E., Gangnon, R., Klein, B.E., The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes (2008) Ophthalmology, 115, pp. 1859-1868
dc.descriptionKlein, R., Lee, K.E., Gangnon, R.E., Klein, B.E., The 25-year incidence of visual impairment in type 1 diabetes mellitus the wisconsin epidemiologic study of diabetic retinopathy (2010) Ophthalmology, 117, pp. 63-70
dc.descriptionRodrigues, T.C., Canani, L.H., Viatroski, R.S., Hoffmann, L.H., Esteves, J.F., Gross, J.L., Masked hypertension, nocturnal blood pressure and retinopathy in normotensive patients with type 1 diabetes (2010) Diabetes Res Clin Pract, 87, pp. 240-245
dc.descriptionKorner, A., Jaremko, G., Eklof, A.-C., Aperia, A., Rapid development of glomerulosclerosis in diabetic Dahl salt-sensitive rats (1997) Diabetologia, 40 (4), pp. 367-373. , DOI 10.1007/s001250050689
dc.descriptionMauer, S.M., Steffes, M.W., Azar, S., The effects of Goldblatt hypertension on development of the glomerular lesions of diabetes mellitus in the rat (1978) Diabetes, 27 (7), pp. 738-744
dc.descriptionWakisaka, M., Nunoi, K., Iwase, M., Kikuchi, M., Maki, Y., Yamamoto, K., Sadoshima, S., Fujishima, M., Early development of nephropathy in a new model of spontaneously hypertensive rat with non-insulin-dependent diabetes mellitus (1988) Diabetologia, 31, pp. 291-296
dc.descriptionCooper, M.E., Allen, T.J., O'Brien, R.C., Macmillan, P.A., Clarke, B., Jerums, G., Doyle, A.E., Effects of genetic hypertension on diabetic nephropathy in the rat - functional and structural characteristics (1988) Journal of Hypertension, 6 (12), pp. 1009-1016. , DOI 10.1097/00004872-198812000-00009
dc.descriptionDosso, A.A., Leuenberger, P.M., Rungger-Brandle, E., Remodeling of retinal capillaries in the diabetic hypertensive rat (1999) Investigative Ophthalmology and Visual Science, 40 (10), pp. 2405-2410
dc.descriptionHammes, H.-P., Brownlee, M., Edelstein, D., Saleck, M., Martin, S., Federlin, K., Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat (1994) Diabetologia, 37 (1), pp. 32-35
dc.descriptionGin, T., Troy Lim Joon, Panagiotopoulos, S., Cooper, M., Taylor, H., Jerums, G., Organ specificity of antihypertensive therapy on ocular albumin vascular clearance and albuminuria in the hypertensive diabetic rat (1996) Investigative Ophthalmology and Visual Science, 37 (2), pp. 281-289
dc.descriptionRighetti, A.E., Boer-Lima, P.A., Lopes De Faria, J.B., The presence of genetic hypertension stimulates early renal accumulation of fibronectin in experimental diabetes mellitus (2001) Diabetologia, 44 (11), pp. 2088-2091. , DOI 10.1007/s001250100014
dc.descriptionLopes De Faria, J.M., Silva, K.C., Boer, P.A., Cavalcanti, T.C., Rosales, M.A., Ferrari, A.L., Lopes De Faria, J.B., A decrease in retinal progenitor cells is associated with early features of diabetic retinopathy in a model that combines diabetes and hypertension (2008) Mol Vis, 14, pp. 1680-1691
dc.descriptionWolf, G., Cell cycle regulation in diabetic nephropathy (2000) Kidney Int, 77, pp. S59-S66
dc.descriptionWolf, G., Schroeder, R., Thaiss, F., Ziyadeh, F.N., Helmchen, U., Stahl, R.A.K., Glomerular expression of p27(Kip1) in diabetic db/db mouse: Role of hyperglycemia (1998) Kidney International, 53 (4), pp. 869-879. , DOI 10.1111/j.1523-1755.1998.00829.x
dc.descriptionWolf, G., Schanze, A., Stahl, R.A.K., Shankland, S.J., Amann, K., p27 Kip1 knockout mice are protected from diabetic nephropathy: Evidence for p27 Kip1 haplotype insufficiency (2005) Kidney International, 68 (4), pp. 1583-1589. , DOI 10.1111/j.1523-1755.2005.00570.x, PII 4494761
dc.descriptionSilveira, L.A., Bacchi, C.E., Pinto, G.A., Lopes De Faria, J.B., The genetics of hypertension modifies the renal cell replication response induced by experimental diabetes (2002) Diabetes, 51 (5), pp. 1529-1534
dc.descriptionCarmines, P.K., The renal vascular response to diabetes (2010) Curr Opin Nephrol Hypertens, 19, pp. 85-90
dc.descriptionGruden, G., Zonca, S., Hayward, A., Thomas, S., Maestrini, S., Gnudi, L., Viberti, G., Mechanical stretch-induced fibronectin and transforming growth factor- β1 production in human mesangial cells is p38 mitogen-activated protein kinase-dependent (2000) Diabetes, 49 (4), pp. 655-661
dc.descriptionRassam, S.M., Patel, V., Kohner, E.M., The effect of experimental hypertension on retinal vascular autoregulation in humans: A mechanism for the progression of diabetic retinopathy (1995) Exp Physiol, 80, pp. 53-68
dc.descriptionAiello, L.P., Avery, R.L., Arrigg, P.G., Keyt, B.A., Jampel, H.D., Shah, S.T., Pasquale, L.R., King, G.L., Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders (1994) New England Journal of Medicine, 331 (22), pp. 1480-1487. , DOI 10.1056/NEJM199412013312203
dc.descriptionSeko, Y., Seko, Y., Fujikura, H., Pang, J., Tokoro, T., Shimokawa, H., Induction of vascular endothelial growth factor after application of mechanical stress to retinal pigment epithelium of the rat in vitro (1999) Invest Ophthalmol Vis Sci, 40, pp. 3287-3291
dc.descriptionSuzuma, I., Hata, Y., Clermont, A., Pokras, F., Rook, S.L., Suzuma, K., Feener, E.P., Aiello, L.P., Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2: Potential mechanisms for exacerbation of diabetic retinopathy by hypertension (2001) Diabetes, 50 (2), pp. 444-454
dc.descriptionSuzuma, I., Suzuma, K., Ueki, K., Hata, Y., Feener, E.P., King, G.L., Aiello, L.P., Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-ζ but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways (2002) Journal of Biological Chemistry, 277 (2), pp. 1047-1057. , DOI 10.1074/jbc.M105336200
dc.descriptionSuzuma, I., Murakami, T., Suzuma, K., Kaneto, H., Watanabe, D., Ojima, T., Honda, Y., Yoshimura, N., Cyclic stretch-induced reactive oxygen species generation enhances apoptosis in retinal pericytes through c-Jun NH2-terminal kinase activation (2007) Hypertension, 49 (2), pp. 347-354. , DOI 10.1161/01.HYP.0000253535.26659.2f, PII 0000426820070200000020
dc.descriptionBeltramo, E., Berrone, E., Giunti, S., Gruden, G., Perin, P.C., Porta, M., Effects of mechanical stress and high glucose on pericyte proliferation, apoptosis and contractile phenotype (2006) Experimental Eye Research, 83 (4), pp. 989-994. , DOI 10.1016/j.exer.2006.05.008, PII S0014483506002612
dc.descriptionMizutani, M., Kern, T.S., Lorenzi, M., Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy (1996) Journal of Clinical Investigation, 97 (12), pp. 2883-2890
dc.descriptionPfister, F., Feng, Y., Vom Hagen, F., Hoffmann, S., Molema, G., Hillebrands, J.L., Shani, M., Hammes, H.P., Pericyte migration: A novel mechanism of pericyte loss in experimental diabetic retinopathy (2008) Diabetes, 57, pp. 2495-2502
dc.descriptionYasuda, T., Kondo, S., Homma, T., Harris, R.C., Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells (1996) Journal of Clinical Investigation, 98 (9), pp. 1991-2000
dc.descriptionCortes, P., Zhao, X., Riser, B.L., Narins, R.G., Role of glomerular mechanical strain in the pathogenesis of diabetic nephropathy (1997) Kidney International, 51 (1), pp. 57-68
dc.descriptionRiser, B.L., Ladson-Wofford, S., Sharba, A., Cortes, P., Drake, K., Guerin, C.J., Jerry, Y., Narins, R.G., TGF-β receptor expression and binding in rat mesangial cells: Modulation by glucose and cyclic mechanical strain (1999) Kidney International, 56 (2), pp. 428-439. , DOI 10.1046/j.1523-1755.1999.00600.x
dc.descriptionRiser, B.L., Denichilo, M., Cortes, P., Baker, C., Grondin, J.M., Yee, J., Narins, R.G., Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis (2000) Journal of the American Society of Nephrology, 11 (1), pp. 25-38
dc.descriptionGiunti, S., Pinach, S., Arnaldi, L., Viberti, G., Perin, P.C., Camussi, G., Gruden, G., The MCP-1/ CCR2 system has direct proinflammatory effects in human mesangial cells (2006) Kidney Int, 69, pp. 856-863
dc.descriptionGruden, G., Setti, G., Hayward, A., Sugden, D., Duggan, S., Burt, D., Buckingham, R.E., Viberti, G., Mechanical stretch induces monocyte chemoattractant activity via an NF-κB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: Inhibition by rosiglitazone (2005) Journal of the American Society of Nephrology, 16 (3), pp. 688-696. , DOI 10.1681/ASN.2004030251
dc.descriptionKuroiwa, T., Lee, E.G., Danning, C.L., Illei, G.G., McInnes, I.B., Boumpas, D.T., CD40 ligand-activated human monocytes amplify glomerular inflammatory responses through soluble and cell-to-cell contact-dependent mechanisms (1999) Journal of Immunology, 163 (4), pp. 2168-2175
dc.descriptionMene, P., Pugliese, F., Cinotti, G.A., Adhesion of U-937 monocytes induces cytotoxic damage and subsequent proliferation of cultured human mesangial cells (1996) Kidney International, 50 (2), pp. 417-423
dc.descriptionGruden, G., Thomas, S., Burt, D., Zhou, W., Chusney, G., Gnudi, L., Viberti, G., Interaction of angiotensin II and mechanical stretch on vascular endothelial growth factor production by human mesangial cells (1999) Journal of the American Society of Nephrology, 10 (4), pp. 730-737
dc.descriptionThomas, S., Vanuystel, J., Gruden, G., Rodriguez, V., Burt, D., Gnudi, L., Hartley, B., Viberti, G., Vascular endothelial growth factor receptors in human mesangium in vitro and in glomerular disease (2000) Journal of the American Society of Nephrology, 11 (7), pp. 1236-1243
dc.descriptionAmemiya, T., Sasamura, H., Mifune, M., Kitamura, Y., Hirahashi, J., Hayashi, M., Saruta, T., Vascular endothelial growth factor activates MAP kinase and enhances collagen synthesis in human mesangial cells (1999) Kidney International, 56 (6), pp. 2055-2063. , DOI 10.1046/j.1523-1755.1999.00796.x
dc.descriptionGnudi, L., Viberti, G.C., Raij, L., Rodriguez, V., Burt, D., Cortes, P., Hartley, B., Gruden, G., GLUT-1 overexpression: Link between hemodynamic and metabolic factors in glomerular injury? (2003) Hypertension, 42 (1), pp. 19-24. , DOI 10.1161/01.HYP.0000075949.19968.EF
dc.descriptionHeilig, C.W., Concepcion, L.A., Riser, B.L., Freytag, S.O., Zhu, M., Cortes, P., Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype (1995) J Clin Invest, 96, pp. 1802-1814
dc.descriptionShankland, S.J., The podocyte's response to injury: Role in proteinuria and glomerulosclerosis (2006) Kidney International, 69 (12), pp. 2131-2147. , DOI 10.1038/sj.ki.5000410, PII 5000410
dc.descriptionWhite, K.E., Bilous, R.W., Cordonnier, D.J., Pinel, N., Barro, C., Halimi, S., Chopinet, P., Mezin, P., Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients (2004) Nephrology Dialysis Transplantation, 19 (6), pp. 1437-1440. , DOI 10.1093/ndt/gfh129
dc.descriptionEndlich, N., Kress, K.R., Reiser, J., Uttenweiler, D., Kriz, W., Mundel, P., Endlich, K., Podocytes respond to mechanical stress in vitro (2001) Journal of the American Society of Nephrology, 12 (3), pp. 413-422
dc.descriptionEndlich, N., Endlich, K., Stretch, tension and adhesion- adaptive mechanisms of the actin cytoskeleton in podocytes (2006) Eur J Cell Biol, 85, pp. 229-234
dc.descriptionDessapt, C., Baradez, M.O., Hayward, A., Dei Cas, A., Thomas, S.M., Viberti, G., Gnudi, L., Mechanical forces and TGFbeta1 reduce podocyte adhesion through alpha3beta1 integrin downregulation (2009) Nephrol Dial Transplant, 24, pp. 2645-2655
dc.descriptionPatey, N., Halbwachs-Mecarelli, L., Droz, D., Lesavre, P., Noel, L.H., Distribution of integrin subunits in normal human kidney (1994) Cell Adhesion and Communication, 2 (2), pp. 159-167
dc.descriptionRuoslahti, E., Integrins (1991) J Clin Invest, 87, pp. 1-5
dc.descriptionDurvasula, R.V., Shankland, S.J., Activation of a local renin angiotensin system in podocytes by glucose (2008) Am J Physiol Renal Physiol, 294, pp. F830-F839
dc.descriptionDurvasula, R.V., Petermann, A.T., Hiromura, K., Blonski, M., Pippin, J., Mundel, P., Pichler, R., Shankland, S.J., Activation of a local tissue angiotensin system in podocytes by mechanical strain (2004) Kidney International, 65 (1), pp. 30-39. , DOI 10.1111/j.1523-1755.2004.00362.x
dc.descriptionMiceli, I., Burt, D., Tarabra, E., Camussi, G., Perin, P.C., Gruden, G., Stretch reduces nephrin expression via an angiotensin II-AT(1)-dependent mechanism in human podocytes: Effect of rosiglitazone (2010) Am J Physiol Renal Physiol, 298, pp. F381-F390
dc.descriptionDoublier, S., Salvidio, G., Lupia, E., Ruotsalainen, V., Verzola, D., Deferrari, G., Camussi, G., Nephrin expression is reduced in human diabetic nephropathy: Evidence for a distinct role for glycated albumin and angiotensin II (2003) Diabetes, 52 (4), pp. 1023-1030. , DOI 10.2337/diabetes.52.4.1023
dc.descriptionBonnet, F., Cooper, M.E., Kawachi, H., Allen, T.J., Boner, G., Cao, Z., Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension (2001) Diabetologia, 44 (7), pp. 874-877. , DOI 10.1007/s001250100546
dc.descriptionAmazonas, R.B., Sanita Rde, A., Kawachi, H., De Faria, J.B., Prevention of hypertension with or without renin-angiotensin system inhibition precludes nephrin loss in the early stage of experimental diabetes mellitus (2007) Nephron Physiol, 107, pp. 57-64
dc.descriptionGorin, Y., Block, K., Hernandez, J., Bhandari, B., Wagner, B., Barnes, J.L., Abboud, H.E., Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney (2005) Journal of Biological Chemistry, 280 (47), pp. 39616-39626. , DOI 10.1074/jbc.M502412200
dc.descriptionSusztak, K., Raff, A.C., Schiffer, M., Bottinger, E.P., Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy (2006) Diabetes, 55 (1), pp. 225-233. , http://diabetes.diabetesjournals.org/cgi/reprint/55/1/225, DOI 10.2337/diabetes.55.1.225
dc.descriptionBrownlee, M., The pathobiology of diabetic complications: A unifying mechanism (2005) Diabetes, 54 (6), pp. 1615-1625. , DOI 10.2337/diabetes.54.6.1615
dc.descriptionJones, D.P., Redefining oxidative stress (2006) Antioxidants and Redox Signaling, 8 (9-10), pp. 1865-1879. , DOI 10.1089/ars.2006.8.1865
dc.descriptionHalliwell, B., Whiteman, M., Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean? (2004) British Journal of Pharmacology, 142 (2), pp. 231-255. , DOI 10.1038/sj.bjp.0705776
dc.descriptionHinokio, Y., Suzuki, S., Hirai, M., Chiba, M., Hirai, A., Toyota, T., Oxidative DNA damage in diabetes mellitus: Its association with diabetic complications (1999) Diabetologia, 42 (8), pp. 995-998. , DOI 10.1007/s001250051258
dc.descriptionNishikawa, T., Sasahara, T., Kiritoshi, S., Sonoda, K., Senokuchi, T., Matsuo, T., Kukidome, D., Araki, E., Evaluation of urinary 8-hydroxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes (2003) Diabetes Care, 26 (5), pp. 1507-1512. , DOI 10.2337/diacare.26.5.1507
dc.descriptionHinokio, Y., Suzuki, S., Hirai, M., Suzuki, C., Suzuki, M., Toyota, T., Urinary excretion of 8-oxo-7, 8-dihydro-2¢-deoxyguanosine as a predictor of the development of diabetic nephro-pathy (2002) Diabetologia, 45, pp. 877-882
dc.descriptionWang, Q., Pfister, F., Dorn-Beineke, A., Vom Hagen, F., Lin, J., Feng, Y., Hammes, H.P., Low-dose erythropoietin inhibits oxidative stress and early vascular changes in the experimental diabetic retina (2010) Diabetologia, 53, pp. 1227-1238
dc.descriptionFuruta, T., Saito, T., Ootaka, T., Soma, J., Obara, K., Abe, K., Yoshinaga, K., The role of macrophages in diabetic glomerulosclerosis (1993) American Journal of Kidney Diseases, 21 (5), pp. 480-485
dc.descriptionUtimura, R., Fujihara, C.K., Mattar, A.L., Malheiros, D.M.A.C., Noronha, I.D.L., Zatz, R., Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes (2003) Kidney International, 63 (1), pp. 209-216. , DOI 10.1046/j.1523-1755.2003.00736.x
dc.descriptionTone, A., Shikata, K., Sasaki, M., Ohga, S., Yozai, K., Nishishita, S., Usui, H., Makino, H., Erythromycin ameliorates renal injury via anti-inflammatory effects in experimental diabetic rats (2005) Diabetologia, 48 (11), pp. 2402-2411. , DOI 10.1007/s00125-005-1945-6
dc.descriptionYozai, K., Shikata, K., Sasaki, M., Tone, A., Ohga, S., Usui, H., Okada, S., Makino, H., Methotrexate prevents renal injury in experimental diabetic rats via anti-inflammatory actions (2005) Journal of the American Society of Nephrology, 16 (11), pp. 3326-3338. , DOI 10.1681/ASN.2004111011
dc.descriptionOkada, S., Shikata, K., Matsuda, M., Ogawa, D., Usui, H., Kido, Y., Nagase, R., Makino, H., Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes (2003) Diabetes, 52 (10), pp. 2586-2593. , DOI 10.2337/diabetes.52.10.2586
dc.descriptionChow, F.Y., Nikolic-Paterson, D.J., Ozols, E., Atkins, R.C., Rollin, B.J., Tesch, G.H., Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice (2006) Kidney International, 69 (1), pp. 73-80. , DOI 10.1038/sj.ki.5000014, PII 5000014
dc.descriptionKern, T.S., Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy (2007) Exp Diabetes Res, 2007, p. 95103
dc.descriptionMcLeod, D.S., Lefer, D.J., Merges, C., Lutty, G.A., Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid (1995) Am J Pathol, 147, pp. 642-653
dc.descriptionLimb, G.A., Hickman-Casey, J., Hollifield, R.D., Chignell, A.H., Vascular adhesion molecules in vitreous from eyes with proliferative diabetic retinopathy (1999) Investigative Ophthalmology and Visual Science, 40 (10), pp. 2453-2457
dc.descriptionHernandez, C., Segura, R.M., Fonollosa, A., Carrasco, E., Francisco, G., Simo, R., Interleukin-8, monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy (2005) Diabetic Medicine, 22 (6), pp. 719-722. , DOI 10.1111/j.1464-5491.2005.01538.x
dc.descriptionSilva, K.C., Pinto, C.C., Biswas, S.K., Souza, D.S., Lopes De Faria, J.B., Lopes De Faria, J.M., Prevention of hypertension abrogates early inflammatory events in the retina of diabetic hypertensive rats (2007) Experimental Eye Research, 85 (1), pp. 123-129. , DOI 10.1016/j.exer.2007.03.008, PII S0014483507000899
dc.descriptionCalcutt, N.A., Cooper, M.E., Kern, T.S., Schmidt, A.M., Therapies for hyperglycaemia-induced diabetic complications: From animal models to clinical trials (2009) Nat Rev Drug Discov, 8, pp. 417-429
dc.descriptionVaziri, N.D., Rodriguez-Iturbe, B., Mechanisms of disease: Oxidative stress and inflammation in the pathogenesis of hypertension (2006) Nature Clinical Practice Nephrology, 2 (10), pp. 582-593. , DOI 10.1038/ncpneph0283, PII NCPNEPH0283
dc.descriptionBiswas, S.K., Peixoto, E.B., Souza, D.S., Lopes De Faria, J.B., Hypertension increases pro-oxidant generation and decreases antioxidant defense in the kidney in early diabetes (2008) American Journal of Nephrology, 28 (1), pp. 133-142. , DOI 10.1159/000109993
dc.descriptionDeRubertis, F.R., Craven, P.A., Melhem, M.F., Salah, E.M., Attenuation of Renal Injury in db/db Mice Overexpressing Superoxide Dismutase: Evidence for Reduced Superoxide - Nitric Oxide Interaction (2004) Diabetes, 53 (3), pp. 762-768. , DOI 10.2337/diabetes.53.3.762
dc.descriptionFujita, H., Fujishima, H., Chida, S., Takahashi, K., Qi, Z., Kanetsuna, Y., Breyer, M.D., Takahashi, T., Reduction of renal superoxide dismutase in progressive diabetic nephropathy (2009) J Am Soc Nephrol, 20, pp. 1303-1313
dc.descriptionPeixoto, E.B., Pessoa, B.S., Biswas, S.K., Lopes De Faria, J.B., Antioxidant SOD mimetic prevents NADPH oxidase-induced oxidative stress and renal damage in the early stage of experimental diabetes and hypertension (2009) Am J Nephrol, 29, pp. 309-318
dc.descriptionRibaldo, P.D., Souza, D.S., Biswas, S.K., Block, K., Lopes De Faria, J.M., Lopes De Faria, J.B., Green tea (Camellia sinensis) attenuates nephropathy by downregulating Nox4 NADPH oxidase in diabetic spontaneously hypertensive rats (2009) J Nutr, 139, pp. 96-100
dc.descriptionSilva, K.C., Pinto, C.C., Biswas, S.K., De Faria, J.B.L., De Faria, J.M.L., Hypertension increases retinal inflammation in experimental diabetes: A possible mechanism for aggravation of diabetic retinopathy by hypertension (2007) Current Eye Research, 32 (6), pp. 533-541. , DOI 10.1080/02713680701435391, PII 779875559
dc.descriptionMadsen-Bouterse, S.A., Kowluru, R.A., Oxidative stress and diabetic retinopathy: Patho-physiological mechanisms and treatment perspectives (2008) Rev Endocr Metab Disord, 9, pp. 315-327
dc.descriptionKowluru, R.A., Odenbach, S., Effect of long-term administration of α-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats (2004) Diabetes, 53 (12), pp. 3233-3238. , DOI 10.2337/diabetes.53.12.3233
dc.descriptionDu, Y., Smith, M.A., Miller, C.M., Kern, T.S., Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine (2002) Journal of Neurochemistry, 80 (5), pp. 771-779. , DOI 10.1046/j.0022-3042.2001.00737.x
dc.descriptionPinto, C.C., Silva, K.C., Biswas, S.K., Martins, N., Lopes De Faria, J.B., Lopes de Faria, J.M., Arterial hypertension exacerbates oxidative stress in early diabetic retinopathy (2007) Free Radical Research, 41 (10), pp. 1151-1158. , DOI 10.1080/10715760701632816, PII 782129371
dc.descriptionRosales, M.A., Silva, K.C., Lopes De Faria, J.B., Lopes De Faria, J.M., Exogenous SOD mimetic tempol ameliorates the early retinal changes restablishing the redox status in diabetic hypertensive rats (2010) Invest Ophthalmol Vis Sci, 51, pp. 4327-4336
dc.descriptionSilva, K.C., Rosales, M.A., De Faria, J.B., De Faria, J.M., Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats (2010) Curr Eye Res, 35, pp. 519-528
dc.descriptionSilva, K.C., Rosales, M.A., Biswas, S.K., Lopes De Faria, J.B., Lopes De Faria, J.M., Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes (2009) Diabetes, 58, pp. 1382-1390
dc.descriptionJung, K.-H., Chu, K., Lee, S.-T., Kim, S.-J., Song, E.-C., Kim, E.-H., Park, D.-K., Roh, J.-K., Blockade of AT1 receptor reduces apoptosis, inflammation, and oxidative stress in normotensive rats with intracerebral hemorrhage (2007) Journal of Pharmacology and Experimental Therapeutics, 322 (3), pp. 1051-1058. , http://jpet.aspetjournals.org/cgi/reprint/322/3/1051, DOI 10.1124/jpet.107.120097
dc.descriptionAnderson, S., Role of local and systemic angiotensin in diabetic renal disease (1997) Kidney International, Supplement, 51 (63), pp. S107-S110
dc.descriptionCooper, M.E., The role of the renin-angiotensin-aldosterone system in diabetes and its vascular complications (2004) American Journal of Hypertension, 17 (11 SUPPL.), pp. 16S-20S. , DOI 10.1016/j.amjhyper.2004.08.004, PII S0895706104009586
dc.descriptionLewis, E.J., Hunsicker, L.G., Bain, R.P., Rohde, R.D., The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy (1993) New England Journal of Medicine, 329 (20), pp. 1456-1462. , DOI 10.1056/NEJM199311113292004
dc.descriptionMauer, M., Zinman, B., Gardiner, R., Suissa, S., Sinaiko, A., Strand, T., Drummond, K., Klein, R., Renal and retinal effects of enalapril and losartan in type 1 diabetes (2009) N Engl J Med, 361, pp. 40-51
dc.descriptionChaturvedi, N., Porta, M., Klein, R., Orchard, T., Fuller, J., Parving, H.H., Bilous, R., Sjølie, A.K., Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: Randomised, placebocontrolled trials (2008) Lancet, 372, pp. 1394-1402. , DIRECT Programme Study Group
dc.descriptionEffects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: Results of the HOPE study and MICRO-HOPE substudy (2000) Lancet, 355, pp. 253-259. , Anonymous Heart Outcomes Prevention Evaluation Study Investigators
dc.descriptionRuggenenti, P., Perna, A., Ganeva, M., Ene-Iordache, B., Remuzzi, G., Impact of blood pressure control and angiotensin-converting enzyme inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: A post hoc analysis of the BENEDICT trial (2006) Journal of the American Society of Nephrology, 17 (12), pp. 3472-3481. , DOI 10.1681/ASN.2006060560
dc.descriptionParving, H.H., Lehnert, H., Bröchner-Mortensen, J., Gomis, R., Andersen, S., Arner, P., The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes (2001) N Engl J Med, 345, pp. 870-878. , Irbesartan in patients with type 2 diabetes and Microalbuminuria Study Group
dc.descriptionBrenner, B.M., Cooper, M.E., De Zeeuw, D., Keane, W.F., Mitch, W.E., Parving, H.H., Remuzzi, G., Shahinfar, S., Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy (2001) N Engl J Med, 345, pp. 861-869. , RENAAL Study Investigators
dc.descriptionLewis, E.J., Hunsicker, L.G., Clarke, W.R., Berl, T., Pohl, M.A., Lewis, J.B., Ritz, E., Raz, I., Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes (2001) N Engl J Med, 345, pp. 851-860. , Collaborative Study Group
dc.descriptionSjølie, A.K., Klein, R., Porta, M., Orchard, T., Fuller, J., Parving, H.H., Bilous, R., Chaturvedi, N., DIRECT programme study group: Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): A randomized placebocontrolled trial (2008) Lancet, 372, pp. 1385-1393
dc.descriptionMehdi, U.F., Adams-Huet, B., Raskin, P., Vega, G.L., Toto, R.D., Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy (2009) J Am Soc Nephrol, 20, pp. 2641-2650
dc.descriptionKang, Y.S., Ko, G.J., Lee, M.H., Song, H.K., Han, S.Y., Han, K.H., Kim, H.K., Cha, D.R., Effect of eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats (2009) Nephrol Dial Transplant, 24, pp. 73-84
dc.descriptionFujisawa, G., Okada, K., Muto, S., Fujita, N., Itabashi, N., Kusano, E., Ishibashi, S., Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats (2004) Kidney International, 66 (4), pp. 1493-1502. , DOI 10.1111/j.1523-1755.2004.00913.x
dc.descriptionHan, S.Y., Kim, C.H., Kim, H.S., Jee, Y.H., Song, H.K., Lee, M.H., Han, K.H., Cha, D.R., Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetics rats (2006) J Am Soc Nephrol, 17, pp. 1362-1372
dc.descriptionTakebayashi, K., Matsumoto, S., Aso, Y., Inukai, T., Aldosterone blockade attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy (2006) Journal of Clinical Endocrinology and Metabolism, 91 (6), pp. 2214-2217. , http://jcem.endojournals.org/cgi/reprint/91/6/2214, DOI 10.1210/jc.2005-1718
dc.descriptionXu, Y., Osborne, B.W., Stanton, R.C., Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex (2005) Am J Physiol Renal Physiol, 289, pp. 1040-1047
dc.descriptionLeopold, J.A., Cap, A., Scribner, A.W., Stanton, R.C., Loscalzo, J., Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothe-lial nitric oxide bioavailability (2001) FASEB J, 15, pp. 1771-1773
dc.descriptionLeopold, J.A., Zhang, Y.-Y., Scribner, A.W., Stanton, R.C., Loscalzo, J., Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide (2003) Arteriosclerosis, Thrombosis, and Vascular Biology, 23 (3), pp. 411-417. , DOI 10.1161/01.ATV.0000056744.26901.BA
dc.descriptionXu, Y., Zhang, Z., Hu, J., Stillman, I.E., Leopold, J.A., Handy, D.E., Loscalzo, J., Stanton, R.C., Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria (2010) FASEB J, 24, pp. 609-616
dc.descriptionLeopold, J.A., Dam, A., Maron, B.A., Scribner, A.W., Liao, R., Handy, D.E., Stanton, R.C., Loscalzo, J., Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity (2007) Nat Med, 13, pp. 189-197
dc.descriptionViengchareun, S., Le Menuet, D., Martinerie, L., Munier, M., Pascual-Le Tallec, L., Lombès, M., The mineralocorticoid receptor: Insights into its molecular and (patho)physiological biology (2007) Nucl Recept Signal, 5, pp. e012
dc.descriptionWilkinson-Berka, J.L., Tan, G., Jaworski, K., Miller, A.G., Identification of a retinal aldoster-one system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology (2009) Circ Res, 104, pp. 124-133
dc.descriptionCastrochaves, P., Cerqueira, R., Pintalhao, M., Leite-Moreira, A.F., New pathways of the renin-angiotensin system: The role of ACE2 in cardiovascular pathophysiology and therapy (2010) Expert Opin Ther Targets, 14, pp. 485-496
dc.descriptionOudit, G.Y., Liu, G.C., Zhong, J., Basu, R., Chow, F.L., Zhou, J., Loibner, H., Scholey, J.W., Human recombinant ACE2 reduces the progression of diabetic nephropathy (2010) Diabetes, 59, pp. 529-538
dc.descriptionTikellis, C., Johnston, C.I., Forbes, J.M., Burns, W.C., Thomas, M.C., Lew, R.A., Yarski, M., Cooper, M.E., Identification of angiotensin converting enzyme 2 in the rodent retina (2004) Current Eye Research, 29 (6), pp. 419-427. , DOI 10.1080/02713680490517944
dc.descriptionLuhtala, S., Vaajanen, A., Oksala, O., Valjakka, J., Vapaatalo, H., Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues (2009) J Ocul Pharmacol Ther, 25, pp. 23-28
dc.descriptionBurrell, L.M., Johnston, C.I., Tikellis, C., Cooper, M.E., ACE2, a new regulator of the renin-angiotensin system (2004) Trends in Endocrinology and Metabolism, 15 (4), pp. 166-169. , DOI 10.1016/j.tem.2004.03.001, PII S1043276004000566
dc.descriptionTikellis, C., Johnston, C.I., Forbes, J.M., Burns, W.C., Burrell, L.M., Risvanis, J., Cooper, M.E., Characterization of renal angiotensin - Converting enzyme 2 in diabetic nephropathy (2003) Hypertension, 41, pp. 392-397. , 3 I, DOI 10.1161/01.HYP.0000060689.38912.CB
dc.descriptionDonoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Acton, S., A novel angiotensin-converting enzymerelated carboxypeptidase (ACE2) converts angiotensin i to angio-tensin 1-9 (2000) Circ Res, 87, pp. E1-E9
dc.descriptionReich, H.N., Oudit, G.Y., Penninger, J.M., Scholey, J.W.,
dc.publisher
dc.relationHypertension Research
dc.rightsfechado
dc.sourceScopus
dc.titleThe Contribution Of Hypertension To Diabetic Nephropathy And Retinopathy: The Role Of Inflammation And Oxidative Stress
dc.typeArtículos de revistas


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