Antiangiogenic And Finasteride Therapies: Responses Of The Prostate Microenvironment In Elderly Mice

dc.creatorKido L.A.
dc.creatorHetzl A.C.
dc.creatorCandido E.M.
dc.creatorMontico F.
dc.creatorLorencini R.M.
dc.creatorCagnon V.H.A.
dc.date2014
dc.date2015-06-25T17:56:45Z
dc.date2015-11-26T14:46:34Z
dc.date2015-06-25T17:56:45Z
dc.date2015-11-26T14:46:34Z
dc.date.accessioned2018-03-28T21:56:22Z
dc.date.available2018-03-28T21:56:22Z
dc.identifier
dc.identifierLife Sciences. Elsevier Inc., v. 106, n. 01/02/15, p. 58 - 70, 2014.
dc.identifier243205
dc.identifier10.1016/j.lfs.2014.04.027
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84901689452&partnerID=40&md5=1bd95be3dcdd415b706cb7edac002041
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87107
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87107
dc.identifier2-s2.0-84901689452
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1252893
dc.descriptionAims The aim of this study was to evaluate the structural and molecular effects of antiangiogenic therapies and finasteride on the ventral prostate of senile mice. Main methods 90 male FVB mice were divided into: Young (18 weeks old) and senile (52 weeks old) groups; finasteride group: finasteride (20 mg/kg); SU5416 group: SU5416 (6 mg/kg); TNP-470 group: TNP-470 (15 mg/kg,) and SU5416 + TNP-470 group: similar to the SU5416 and TNP-470 groups. After 21 days, prostate ventral lobes were collected for morphological, immunohistochemical and Western blotting analyses. Key findings The results demonstrated atrophy, occasional proliferative lesions and inflammatory cells in the prostate during senescence, which were interrupted and/or blocked by treatment with antiangiogenic drugs and finasteride. Decreased AR and endostatin reactivities, and an increase for ER-α, ER-β and VEGF, were seen in the senile group. Decreased VEGF and ER-α reactivities and increased ER-β reactivity were verified in the finasteride, SU5416 groups and especially in SU5416 + TNP-470 group. The TNP-470 group showed reduced AR and ER-β protein levels. Significance The senescence favored the occurrence of structural and/or molecular alterations suggesting the onset of malignant lesions, due to the imbalance in the signaling between the epithelium and stroma. The SU5416 + TNP-470 treatment was more effective in maintaining the structural, hormonal and angiogenic factor balance in the prostate during senescence, highlighting the signaling of antiproliferation via ER-β. © 2014 Elsevier Inc.
dc.description106
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dc.languageen
dc.publisherElsevier Inc.
dc.relationLife Sciences
dc.rightsfechado
dc.sourceScopus
dc.titleAntiangiogenic And Finasteride Therapies: Responses Of The Prostate Microenvironment In Elderly Mice
dc.typeArtículos de revistas


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