Influence Of Procainamide On The Neuromuscular Blockade Caused By Rocuronium And Investigation On The Mechanism Of Action Of Procainamide On The Neuromuscular Junction [influência Da Procainamida Sobre O Bloqueio Neuromuscular Produzido Pelo Rocurônio E Investigação Sobre O Mecanismo De Ação Da Procainamida Na Junção Neuromuscular]

dc.creatorMartins T.D.
dc.creatorLoyola Y.C.S.
dc.creatorBraga A.D.F.D.A.
dc.date2007
dc.date2015-06-30T18:40:41Z
dc.date2015-11-26T14:31:24Z
dc.date2015-06-30T18:40:41Z
dc.date2015-11-26T14:31:24Z
dc.date.accessioned2018-03-28T21:34:46Z
dc.date.available2018-03-28T21:34:46Z
dc.identifier
dc.identifierRevista Brasileira De Anestesiologia. , v. 57, n. 1, p. 74 - 82, 2007.
dc.identifier347094
dc.identifier10.1590/S0034-70942007000100008
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-33846626497&partnerID=40&md5=16fe7f35413ce8520a0a2513575e7195
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/104302
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/104302
dc.identifier2-s2.0-33846626497
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1247360
dc.descriptionBACKGROUND AND OBJECTIVES: It has already been proved that procainamide potentiates the neuromuscular blockade of d-tubocurarine; however, the mechanism of this potentiation is controversial. The aim of this study was to assess the influence of procainamide on the neuromuscular blockade produced by rocuronium and investigate the mechanisms of this interaction. METHODS: Fifteen rats (250 to 300 g) were used in the preparation described by Bülbring. They were divided in three groups (n = 5 each): procainamide - 20 μg.mL-1 (Group I); rocuronium - 4 μg.mL-1 (Group II); and rocuronium - 4 μg.mL-1 and procainamide - 20 μg.mL-1 (Group III). The following parameters were evaluated: 1) amplitude of muscle contractions under indirect stimulation, before and after the administration of the drugs; 2) miniature end plate potentials (MEPPs); and 3) the efficacy of 4-aminopyridine in reverting the muscular blockade. The mechanism of the interaction was studied in Biventer cervicis (n = 5) and in the denervated rat diaphragm (n = 5), observing the influence of procainamide in the response to acetylcholine. RESULTS: Procainamide alone did not change the neuromuscular responses. Group III presented a 68.6% ± 7.1% blockade, which represented a statistically significant difference (p = 0.0067) when compared with Group II (10.4% ± 4.5%), which was reverted by 4-aminopiridine. Procainamide increased the frequency of the MEPP, followed by a blockade that was reverted by 4-aminopiridine. In Biventer cervicis, procainamide increased the contraction in response to acetylcholine, which was not observed in the denervated diaphragm. CONCLUSIONS: Procainamide potentiated the blockade caused by rocuronium. The changes observed with MEPP and Biventer cervicis identified pre-synaptic action. The antagonism of 4-aminopiridine on the blockade of the MEPP suggested receptor desensitization by procainamide. © Sociedade Brasileira de Anestesiologia, 2007.
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dc.languagept
dc.languageen
dc.publisher
dc.relationRevista Brasileira de Anestesiologia
dc.rightsfechado
dc.sourceScopus
dc.titleInfluence Of Procainamide On The Neuromuscular Blockade Caused By Rocuronium And Investigation On The Mechanism Of Action Of Procainamide On The Neuromuscular Junction [influência Da Procainamida Sobre O Bloqueio Neuromuscular Produzido Pelo Rocurônio E Investigação Sobre O Mecanismo De Ação Da Procainamida Na Junção Neuromuscular]
dc.typeArtículos de revistas


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