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Reversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration
(Soc Biolgia Chile, 2009-01-01)
The development and validation of a simple and accurate method based on HPLC with ultraviolet detection for the quantification of zidovudine in rat plasma and its application to a pharmacokinetic study following a single ...
Reversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration
(Soc Biolgia Chile, 2009-01-01)
The development and validation of a simple and accurate method based on HPLC with ultraviolet detection for the quantification of zidovudine in rat plasma and its application to a pharmacokinetic study following a single ...
Rapid and sensitive ultra-high-pressure liquid chromatography method for quantification of antichagasic benznidazole in plasma: application in a preclinical pharmacokinetic study
(Wiley-Blackwell, 2015-07-01)
Benznidazole (BNZ) and nifurtimox are the only drugs available for treating Chagas disease. In this work, we validated a bioanalytical method for the quantification of BNZ in plasma aimed at improving sensitivity and time ...
Multichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imaging
(2019-07-01)
In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic ...
Simple and Rapid Method by Ultra High-Performance Liquid Chromatography (UHPLC) with Ultraviolet Detection for Determination of Efavirenz in Plasma: Application in a Preclinical Pharmacokinetic Study
(2019-10-10)
A simple and rapid ultra-high-performance liquid chromatography (UHPLC) method for determination of efavirenz (EFV) in plasma was developed and applied in a preclinical pharmacokinetic study. The method involves only ...
Reversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration
(2009-12-01)
The development and validation of a simple and accurate method based on HPLC with ultraviolet detection for the quantification of zidovudine in rat plasma and its application to a pharmacokinetic study following a single ...
Pharmacokinetics of lysine clonixinate in children in postoperative care
(DUSTRI-VERLAG DR KARL FEISTLE, 1996)
The pharmacokinetics of 2 doses of intravenous lysine clonixinate (4 and 6 mg x kg(-1)) were studied in 10 children (age 4 - 10 years) under postoperative care, A single dose of the drug was injected in a forearm vein, ...
Pharmacokinetics of ketorolac in children after abdominal surgery
(DUSTRI-VERLAG DR KARL FEISTLE, 1997)
The pharmacokinetics of 2 doses of intravenous ketorolac (0.5 and 0.9 mg x kg(-1)) were studied in 14 children (age 2 - 8 years). A single dose of the drug was injected into the dorsum vein of one hand. Blood samples were ...
Models for evaluating the pharmacokinetics and pharmacodynamics for β-blockers
(Informa Healthcare, 2014-04)
Introduction: β-blocker therapy plays an important role in the treatment of various diseases, including hypertension, myocardial infarction and heart failure. Although all β-blockers shared their ability to competitively ...
Preclinical pharmacokinetic study of a new thiazolyl hydrazone derivative with antifungal activity in mice plasma by LC-MS/MS
(Universidade Federal de Minas GeraisBrasilFAR - DEPARTAMENTO DE ALIMENTOSFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSICX - DEPARTAMENTO DE QUÍMICAUFMG, 2020-07-15)