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Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury
(2016)
Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models of spinal cord injury and neurodegeneration, the contribution of this pathway to peripheral nerve ...
Neuroprotective effect of TNFα against the β-amyloid neurotoxicity mediated by CDK5 kinase
(Elsevier B.V., 2006-10-21)
The tumor necrosis factor alpha (TNFα) plays a dual role in producing either neurodegeneration or neuroprotection in the central nervous
system. Despite that TNFα was initially described as a cell death inductor, ...
Neuronal death in Drosophila triggered by GAL4 accumulation
(Wiley, 2007-12)
The GAL4/UAS system has been extensively employed in Drosophila to control gene expression in defined spatial patterns. More recently this system has been successfully applied to express genes involved in neurodegeneration ...
Imatinib therapy blocks cerebellar apoptosis and improves neurological sumptoms in a mouse model of Niemann-Pick type C disease.
(2008)
Niemann-Pick type C (NPC) disease is a fatal autosomal recessive disorder characterized by the accumulation of free cholesterol and glycosphingolipids in the endosomal-lysosomal system. Patients with NPC disease have ...
APP signaling in Alzheimer's disease
(Impact Journals, 2018-11)
A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter ...
Reposicionamento de fármacos na doença de Parkinson: anti-inflamatórios não esteroides como potenciais fármacos para minimizar a neurodegeneração.
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE FARMACOLOGIACurso de Especialização em FarmacologiaUFMG, 2018-06-29)
According to the World Health Organization, neurological disorders such as Parkinson's disease (PD) account for more than 6% of the disease global burden. PD, discovered more than 200 years ago, is characterized by the ...
Disfunção na atividade da citocromo c oxidase (Cox) mitocondrial na doença de Alzheimer: revisão sistemática e metanálise
(Universidade Federal de Minas GeraisUFMG, 2018-03-08)
Introduction: There is evidence that the impairment of mitochondrial functions may contribute to damages in synapses and neurodegeneration, observed in Alzheimer's disease (A.D.). Neurodegeneration may be related to changes ...
Measurement of autophagy flux in the nervous system in vivo
(Macmillan Publishers, 2013)
Accurate methods to measure autophagic activity in vivo in neurons are not available, and most of the studies are based on
correlative and static measurements of autophagy markers, leading to conflicting interpretations. ...
Neuroprotective and Neurotoxic Effects of Glial-Derived Exosomes
(2022-06-22)
Exosomes derived from glial cells such as astrocytes, microglia, and oligodendrocytes can modulate cell communication in the brain and exert protective or neurotoxic effects on neurons, depending on the environmental context ...