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Avaliação da atividade autofágica nos processos neurodegenerativos da via nigroestriatal em modelo experimental da doença de ParkinsonEvaluation of autophagic activity in neurodegenerative processes of the nigrostriatal pathway in experimental model of Parkinson's disease
(Pós-Graduação em Ciências FisiológicasUniversidade Federal de Sergipe (UFS), 2023)
Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
(2010)
Abstract
Background
Septal cholinergic neurons account for most of the cholinergic innervations of the hippocampus, playing a key role in the regulation of hippocampal ...
Lack of Jun-N-terminal kinase 3 (JNK3) does not protect against neurodegeneration induced by 3-nitropropionic acid
(2012)
Aims: 3-Nitropropionic acid (3-NP) is a toxin that replicates most of the clinical and pathophysiological symptoms of Huntington's disease, inducing neurodegeneration in the striatum due to the inhibition of mitochondrial ...
Lack of Jun-N-terminal kinase 3 (JNK3) does not protect against neurodegeneration induced by 3-nitropropionic acid
(2012)
Aims: 3-Nitropropionic acid (3-NP) is a toxin that replicates most of the clinical and pathophysiological symptoms of Huntington's disease, inducing neurodegeneration in the striatum due to the inhibition of mitochondrial ...
Dissecting the role of redox signaling in neuronal development
(2016)
Abstract: The generation of abnormally high levels of reactive oxygen species (ROS) is linked to cellular dysfunction, including neuronal toxicity and neurodegeneration. However, physiological ROS production modulates ...
Contribution of nadph-oxidase to the establishment of hippocampal neuronal polarity in culture
(2015)
Reactive oxygen species (ROS) produced by the NADPH oxidase (NOX) complex play important physiological and pathological roles in neurotransmission and neurodegeneration, respectively. However, the contribution of ROS to ...
Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia
(2017)
Biomarkers represent a critical research area in neurodegeneration disease as they can contribute to studying potential disease-modifying agents, fostering timely therapeutic interventions, and alleviating associated ...
Dissecting the role of redox signaling in neuronal development
(2016)
The generation of abnormally high levels of reactive oxygen species (ROS) is linked to cellular dysfunction, including neuronal toxicity and neurodegeneration. However, physiological ROS production modulates redox-sensitive ...
The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics
(2017)
Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This ...
Heparin Activates Wnt Signaling for Neuronal Morphogenesis
(2008)
Wnt factors are secreted ligands that affect different aspects of the nervous system behavior like neurodevelopment, synaptogenesis and neurodegeneration. In different model systems, Wnt signaling has been demonstrated to ...