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The potential role of protein kinase R as a regulator of age-related neurodegeneration
(Frontiers Media, 2021)
There is a growing evidence describing a decline in adaptive homeostasis in agingrelated
diseases affecting the central nervous system (CNS), many of which are
characterized by the appearance of non-native protein ...
Role of Ca2+ signaling in mitochondrial dysfunction as a basis of neurodegeneration in early-onset familial Alzheimer’s disease
(Universidad de Chile, 2021)
Familial Alzheimer’s disease (FAD) is characterized by autosomal-dominant
heritability and early onset. Mutations in the gene encoding presenilin-1 (PS1) are
found in approximately 80% of cases of FAD. The etiology of ...
Imaging biomarkers in neurodegeneration: current and future practices
(BMC, 2020)
There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically for the in vivo investigation of ...
Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
(2008)
Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in ...
Iron and glutathione at the crossroad of redox metabolism in neurons
(2006)
Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In
particular, there is increasing evidence that iron progressively accumulates in the brain with age and that ...
The Genetic Diagnosis of Neurodegenerative Diseases and Therapeutic Perspectives
(Brain Sciences, 2018-12-13)
Genetics has led to a new focus regarding approaches to the most prevalent diseases today. Ascertaining the molecular secrets of neurodegenerative diseases will lead to developing drugs that will change natural history, ...
Measurement of autophagy flux in the nervous system in vivo
(NATURE PUBLISHING GROUP, 2013)
Accurate methods to measure autophagic activity in vivo in neurons are not available, and most of the studies are based on correlative and static measurements of autophagy markers, leading to conflicting interpretations. ...
Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders
(2015)
Ascorbic acid is a key antioxidant of the Central Nervous System (CNS). Under brain activity, ascorbic acid is released from glial reservoirs to the synaptic cleft, where it is taken up by neurons. In neurons, ascorbic ...