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Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation
(American Society for Biochemistry and Molecular Biology, 2020-07)
Niemann–Pick type C (NPC) disease is a lysosomal storage disorder arising from mutations in the cholesterol-trafficking protein NPC1 (95%) or NPC2 (5%). These mutations result in accumulation of low-density lipoprotein-derived ...
Evaluation of Cerebrospinal Fluid Neurofilament Light Chain as a Routine Biomarker in a Memory Clinic
(Gerontological Soc Amer, 2019-03)
Systematic evaluation of biomarkers in representative populations is needed to validate their clinical utility. In this work, we assessed the diagnostic performance of cerebrospinal fluid (CSF) neurofilament light chain ...
Myelin-associated glycoprotein activation triggers glutamate uptake by oligodendrocytes in vitro and contributes to ameliorate glutamate-mediated toxicity in vivo
(Elsevier Science, 2022-04)
Background: Myelin-associated glycoprotein (MAG) is a key molecule involved in the nurturing effect of myelin on ensheathed axons. MAG also inhibits axon outgrowth after injury. In preclinical stroke models, administration ...
Rejuvenating Effect of Long-Term Insulin-Like Growth Factor-I Gene Therapy in the Hypothalamus of Aged Rats with Dopaminergic Dysfunction
(Mary Ann Liebert, 2018-04)
The aging female rat constitutes an interesting model of spontaneous and progressive age-related dopaminergic dysfunction as it allows assessing new therapeutic strategies for Parkinson's disease. Insulin-like growth factor ...
Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease
(Pergamon-Elsevier Science Ltd, 2020-04)
Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays ...
Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease
(Humana Press Inc., 2018)
Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review
(The Royal Society Publishing, 2022)
Developmental signalling pathways such as Wnt/beta-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term 'embryonic' might appear to be a misnomer to several people ...
The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein
(Amer Soc Biochemistry Molecular Biology, 2015)
Although the accumulation of a misfolded and protease-resistant form of the prion protein (PrP) is a key event in prion pathogenesis, the cellular factors involved in its folding and quality control are poorly understood. ...
Isquemia cerebral experimental y sus aplicaciones en la investigación en neurociencias
(Universidad del Norte, 2013)