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Fungi that Infect Humans
(Amer Soc Microbiology, 2017)
Fungi must meet four criteria to infect humans: growth at human body temperatures, circumvention or penetration of surface barriers, lysis and absorption of tissue, and resistance to immune defenses, including elevated ...
Intermolecular interactions of the malate synthase of Paracoccidioides spp
(2013-05-16)
Background: The fungus Paracoccidioides spp is the agent of paracoccidioidomycosis (PCM), a pulmonary mycosis acquired by the inhalation of fungal propagules. Paracoccidioides malate synthase (PbMLS) is important in the ...
Intermolecular interactions of the malate synthase of Paracoccidioides spp
(2013-05-16)
Background: The fungus Paracoccidioides spp is the agent of paracoccidioidomycosis (PCM), a pulmonary mycosis acquired by the inhalation of fungal propagules. Paracoccidioides malate synthase (PbMLS) is important in the ...
Dual localization of Mdj1 in pathogenic fungi varies with growth temperature
(Informa Healthcare, 2014-02-01)
Paracoccidioides brasiliensis and P. lutzii are temperature-dependent dimorphic fungi that cause paracoccidioidomycosis (PCM). Previously, we characterized the PbMDJ1 gene. This gene encodes P. brasiliensis chaperone Mdj1, ...
Down-regulation of TUFM impairs host cell interaction and virulence by Paracoccidioides brasiliensis
(2019-12-01)
The genus Paracoccidioides consist of dimorphic fungi geographically limited to the subtropical regions of Latin America, which are responsible for causing deep systemic mycosis in humans. However, the molecular mechanisms ...
Differential miRNA expression in human macrophage-like cells infected with histoplasma capsulatum yeasts cultured in planktonic and biofilm forms
(2021-01-01)
Histoplasma capsulatum affects healthy and immunocompromised individuals, sometimes causing a severe disease. This fungus has two morphotypes, the mycelial (infective) and the yeast (parasitic) phases. MicroRNAs (miRNAs) ...
The fungal cell wall: candida, cryptococcus, and aspergillus species
(Frontiers Media, 2020)
A Temperature-Responsive Network Links Cell Shape and Virulence Traits in a Primary Fungal Pathogen
(Public Library of Science, 2013-07)
Survival at host temperature is a critical trait for pathogenic microbes of humans. Thermally dimorphic fungal pathogens, including Histoplasma capsulatum, are soil fungi that undergo dramatic changes in cell shape and ...
Paracoccidioides brasiliensis downmodulates α3 integrin levels in human lung epithelial cells in a TLR2-dependent manner
(Nature, 2020-11-10)
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America and may be caused by the species Paracoccidioides brasiliensis. In the lungs, this fungus interacts with epithelial cells, activating ...