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First in vivo evaluation of the mutagenic effect of Brazilian green propolis by comet assay and micronucleus test
(Pergamon-Elsevier B.V. Ltd, 2008-07-01)
Propolis is a hive product containing chiefly beeswax and plant-derived substances such as resin and volatile compounds. Propolis has been used in various parts of the world as an antiseptic and wound healer since ancient ...
Toxicity of dietary restriction of fat enriched diets on cardiac tissue
(Elsevier B.V., 2002-12-01)
The present study examines the effects of caloric restriction in cardiac tissue evaluation markers of oxidative stress. High-fat dietary restrictions can have a long-term impact on cardiac health. Dietary restriction of ...
Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice
(Pergamon-Elsevier B.V. Ltd, 2011-06-01)
Artesunate is a derivate of artemisinin that is both an antimalarial agent and acts cytotoxically on tumor cells. Despite its therapeutic use, its in vivo genotoxic potential has still not been evaluated. This study, ...
Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo
(Elsevier B.V., 2007-05-01)
Anthocyanins are the largest group of water-soluble pigments in the plant kingdom. A number of studies have demonstrated that anthocyanins present antioxidant capacity and show inhibitory effects on the growth of some ...
Lack of chemopreventive effects of ginger on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats
(Elsevier B.V., 2006-06-01)
Ginger (Zingiber officinale Roscoe) has been proposed as a promising candidate for cancer prevention. Its modifying potential on the process of colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) was investigated ...
STORAGE RESULTS IN LOSS of THE ANTIGENOTOXIC PROPERTIES of LENTINULA EDODES (SHIITAKE MUSHROOM) and DEVELOPMENT of IN VIVO GENOTOXICITY
(Wiley-Blackwell Publishing, Inc, 2010-02-01)
In this study, we have investigated the stability of the antigenotoxic properties of dried of Lentinula edodes (Berk.) Singer mushroom powder stored at room and at -20C. Mice were pretreated by gavage for 15 consecutive ...
Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat
(Elsevier B.V., 2003-11-01)
The chemopreventive potential of an Agaricus blazei (Ab) Murrill mushroom meal was investigated in a medium-term rat liver carcinogenesis assay. Male Wistar rats initiated for hepatocarcinogenesis with diethylnitrosamine ...
Mate attenuates DNA damage and carcinogenesis induced by diethylnitrosamine and thermal injury in rat esophagus
(Pergamon-Elsevier B.V. Ltd, 2009-07-01)
Drinking hot mate has been associated with risk for esophageal cancer in South America. Thus. the aims of this study were to evaluate the modifying effects of mate intake on DNA damage and esophageal carcinogenesis induced ...
Effects of lycopene, synbiotic and their association on early biomarkers of rat colon carcinogenesis
(Pergamon-Elsevier B.V. Ltd, 2010-03-01)
This study evaluated whether a synergy exists for the combined treatment with lycopene and synbiotic on early biomarkers; of colon carcinogenesis. Male Wistar rats received a diet containing 300 mg/kg of lycopene and/or ...
Cholesterol reduction and lack of genotoxic or toxic effects in mice after repeated 21-day oral intake of lemongrass (Cymbopogon citratus) essential oil
(Pergamon-Elsevier B.V. Ltd, 2011-09-01)
Cymbopogon citratus (lemongrass) is currently used in traditional folk medicine. Although this species presents widespread use, there are no scientific data on its efficacy or safety after repeated treatments. Therefore, ...