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Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies
(SAGE Publications, 2015)
A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus. Female rats had greater oxfendazole exposure and exhibited toxicities at lower doses ...
Statins in liver cirrhosis in a developing country: benefits overweigh the risk?
(Taylor & FrancisPE, 2020)
El artículo destaca la evidencia a favor del uso de simvastatina, en pacientes con cirrosis hepática, superando los riesgos que antes se temía. Fomentando su implementación como parte del manejo integral de todos los ...
Drug repositioning: current approaches and their implications in the precision medicine era
(Taylor & Francis, 2018-01)
Introduction: Drug repositioning implies finding new medical uses for existing drugs. It represents a cost-efficient approach, since the new indications are built on the basis of available information on pharmacokinetics, ...
An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens: study protocol for a randomized controlled trial
(BioMed Central, 2017)
BACKGROUND: Current guidelines for treatment of multidrug-resistant tuberculosis (MDR-TB) are largely based on expert opinion and observational data. Fluoroquinolones remain an essential part of MDR-TB treatment, but the ...
Determination of the frequency and direct cost of the adverse drug events in Argentina
(Bentham Science Publishers, 2009-04)
To determine the frequency and the direct costs of adverse drug reactions, in an ambulatory population of the City of Buenos Aires, Argentina and its area of influence. A retrospective study was done during a period of ...
Cystic echinococcosis: Chronic, complex, and still neglected
(Public Library of Science, 2011)
Cystic echinococcosis (CE), an infection with the larval form of the dog tapeworm Echinococcus granulosus, still causes serious lung and liver disease with a worldwide geographical distribution. This parasitic infection ...
Efficacy and safety of oncoplastic surgery plus drug therapy for chronic tuberculous granulomatous mastitis
(Universidad Continental, 2020-06-01)
BACKGROUND: Chronic tuberculous granulomatous mastitis (CTGM) is a rare form of tuberculosis (TB) treated primarily with anti-TB drugs. Oncoplastic surgery (OS) has been proposed as adjuvant therapy for CTGM.
METHOD: ...
Multidrug-resistant tuberculosis and culture conversion with bedaquiline
(Massachusetts Medical Society, 2014)
BACKGROUND: Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when ...
In silico drug repositioning for chagas disease
(Bentham Science Publishers, 2020)
Chagas disease is an infectious tropical disease included within the group of neglected tropical diseases. Though historically endemic to Latin America, it has lately spread to high-income countries due to human migration. ...
Repurposing drugs to target nonalcoholic steatohepatitis
(W J G Press, 2019-04-21)
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage. The main obstacle to better disease management pertains to the lack of ...