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Reinforcing properties of fencamfamine: Involvement of dopamine and opioid receptors
(1995-01-17)
Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had ...
Reinforcing properties of fencamfamine: Involvement of dopamine and opioid receptors
(1995-01-17)
Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had ...
Functional roles of T3.37 and S5.46 in the activation mechanism of the dopamine D1 receptor
(Springer Verlag, 2017)
© 2017, Springer-Verlag Berlin Heidelberg. The activation mechanism of dopamine receptors is unknown. The amino acids S5.42, S5.43, and S5.46 located in helix 5 appear to be crucial, but their specific roles in receptor ...
Behavioral indices of moderate nigrostriatal 6–hydroxydopamine lesion: a preclinical Parkinson's model.
(1993-02)
Asymmetries in turning and scanning were investigated in rats with different degrees of neostriatal dopamine depletion after unilateral injections of 6-hydroxydopamine into the substantia nigra. Animals with severe lesions, ...
Behavioral indices of moderate nigrostriatal 6–hydroxydopamine lesion: a preclinical Parkinson's model.
(1993-02)
Asymmetries in turning and scanning were investigated in rats with different degrees of neostriatal dopamine depletion after unilateral injections of 6-hydroxydopamine into the substantia nigra. Animals with severe lesions, ...
Theoretical study of dopamine. Application of the HSAB principle to the study of drug-receptor interactions
(Elsevier, 2000)
We present a theoretical conformational study of neutral and N- protonated form of dopamine in which we relate its pharmacological activity to the chemical hardness. We have found that the neutral form presents small ...
Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors
(Frontiers Media, 2020)
The strength of goal-oriented behaviors is regulated by midbrain dopamine neurons. Dysfunctions of dopaminergic circuits are observed in drug addiction and obsessive-compulsive disorder. Compulsive behavior is a feature ...