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Mostrando ítems 4651-4660 de 10759
Preparation of sesquiterpene lactone derivatives: Cytotoxic activity and selectivity of action
(Molecular Diversity Preservation International, 2019-03)
Cancer is one of the most important causes of death worldwide. Solid tumors represent the great majority of cancers (>90%) and the chemotherapeutic agents used for their treatment are still characterized by variable efficacy ...
Single-domain antibodies and the promise of modular targeting in cancer imaging and treatment
(Frontiers Research Foundation, 2018-02)
Monoclonal antibodies and their fragments have significantly changed the outcome of cancer in the clinic, effectively inhibiting tumor cell proliferation, triggering antibody-dependent immune effector cell activation and ...
ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner
(Landes Bioscience, 2012-11)
Autophagy is a normal degradative pathway that involves the sequestration of cytoplasmic components and organelles in a vacuole called autophagosome. SNAREs proteins are key molecules of the vesicle fusion machinery. Our ...
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
(Pergamon-Elsevier Science Ltd, 2004-04)
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases ...
Nutraceutic Potential of Two Allium Species and Their Distinctive Organosulfur Compounds: A Multi-Assay Evaluation
(Multidisciplinary Digital Publishing Institute, 2019-06-21)
This study aimed to evaluate the biological activities of two Allium species (garlic and onion) as well as diallyl disulphide (DADS) and dipropyl disulphide (DPDS) as their representative bioactive compounds in a multi-assay ...
Lipid metabolism alterations in the neuronal response to A53T α-synuclein and Fe-induced injury
(Elsevier Science Inc, 2018-10-08)
Pathological α-synuclein (α-syn) overexpression and iron (Fe)-induced oxidative stress (OS) are involved in the death of dopaminergic neurons in Parkinson's disease (PD). We have previously characterized the role of ...
Antitumor properties of a vanadyl(IV) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: the role of oxidative stress and apoptosis
(Royal Society of Chemistry, 2013-05)
Flavonoids, a polyphenolic compound family, and the vanadium compounds have interesting biological, pharmacological, and medicinal properties. We report herein the antitumor actions of the complex [VO(chrysin)2EtOH]2 ...
Sertoli–immature spermatids disengagement during testis regression in the armadillo
(BioScientifica, 2019-01)
In nature, mammalian seasonal breeders undergo spermatogenetic arrest during the non-breeding season. In the large hairy armadillo Chaetophractus villosus, testis regression initiates with immature post-meiotic germ cells ...
On the discovery of a potential survivin inhibitor combining computational tools and cytotoxicity studies
(Elsevier, 2019-08-01)
Survivin protein is a metalloprotein member of the inhibitors of apoptosis proteins family, involved in the regulation of programmed cell death. Due to the recent development of antitumor therapies having survivin as ...
Desenvolvimento de ferramentas para a identificação de marcadores moleculares e imunológicos a partir de dados genômicos como alvo para o diagnóstico de doenças parasitárias
(Universidade Federal de Minas GeraisUFMG, 2015-08-26)
Infectious diseases caused by protozoan parasites is a major public health problem, especially in poor or developing, causing millions of deaths annually. For effective monitoring and control of these diseases it is essential ...