Buscar
Mostrando ítems 1-10 de 19
Biosynthesis of SUMOylated proteins in bacteria using the trypanosoma brucei enzymatic system
(Public Library of Science, 2015-08)
Post-translational modification with the Small Ubiquitin-like Modifier (SUMO) is conserved in eukaryotic organisms and plays important regulatory roles in proteins affecting diverse cellular processes. In Trypanosoma brucei, ...
MxA interacts with and is modified by the SUMOylation machinery
(Elsevier B.V., 2015-01-01)
Mx proteins are evolutionarily conserved dynamin-like large GTPases involved in viral resistance triggered by types I and III interferons. The human MxA is a cytoplasmic protein that confers resistance to a large number ...
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation
(Springer, 2015-05)
Extracellular α-Synuclein has been implicated in interneuronal propagation of disease pathology in Parkinson’s Disease. How α-Synuclein is released into the extracellular space is still unclear. Here, we show that α-Synuclein ...
Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3
(ElsevierAmsterdam, 2012)
MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs
(Nature Publishing Group, 2012-06)
MAGE-A genes are a subfamily of the melanoma antigen genes (MAGEs), whose expression is restricted to tumor cells of different origin and normal tissues of the human germline. Although the specific function of individual ...
Tools to Study SUMO Conjugation in Caenorhabditis elegans
(Springer, 2016-09-06)
The cell biology of sumoylation has mostly been studied using transformed cultured cells and yeast. Inrecent years, genetic analysis has demonstrated important roles for sumoylation in the biology of C. elegans. Here, we ...
In silico structural and functional characterization of the RSUME splice variants Short title: RSUME splice variants
(Public Library Science, 2013-02)
RSUME (RWD-containing SUMO Enhancer) is a small protein that increases SUMO conjugation to proteins. To date, four splice variants that codify three RSUME isoforms have been described, which differ in their C-terminal end. ...
Human stanniocalcin-1 interacts with nuclear and cytoplasmic proteins and acts as a SUMO E3 ligase
(Royal Soc ChemistryCambridgeInglaterra, 2011)
Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
ARHGAP21 is a 217 kDa RhoGAP protein shown to modulate cell migration through the control of Cdc42 and FAK activities. In the present work a 250 kDa-ARHGAP21 was identified by mass spectrometry. This modified form is ...
Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
(2011-12-01)
The Mx1 protein is encoded by an interferon- induced gene and shares domain organization, homooligomerization capacity and membrane association with the large dynamin-like GTPases. The Mx1 protein is involved in the response ...