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Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage
(2013-03-01)
Objectives were to evaluate the role of canonical WNT signaling in development of the preimplantation embryo. Signaling was activated with 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP) ...
Long Signaling Cascades Tend to Attenuate Retroactivity
(Cell Press, 2011-04)
Signaling pathways consisting of phosphorylation/dephosphorylation cycles with no explicit feedback allow signals to propagate not only from upstream to downstream but also from downstream to upstream due to retroactivity ...
G protein-coupled receptor signal transduction and Ca2+ signaling pathways of the allatotropin/orexin system in Hydra
(Academic Press Inc Elsevier Science, 2021-01-01)
Allatotropin is a pleiotropic peptide originally characterized in insects. The existence of AT neuropeptide signaling was proposed in other invertebrates. In fact, we previously proposed the presence of an AT-like system ...
Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease
(NLM (Medline), 2020)
Persistent activation of the mammalian target of rapamycin signaling pathway in cutaneous squamous cell carcinomas in cats
(Wiley Blackwell Publishing, Inc, 2021-07)
Background: Cutaneous squamous cell carcinoma (CSCC) represents the most common malignant tumour of the feline skin. Emerging evidence suggests that the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin ...
Cross-talk between mitochondrial function, growth, and stress signalling pathways in plants
(Oxford University Press, 2020-12)
Plant mitochondria harbour complex metabolic routes that are interconnected with those of other cell compartments and changes in mitochondrial function remotely influence processes in different parts of the cell. This ...
Sonidegib en el tratamiento del carcinoma basocelular localmente avanzado
Sonidegib is an antagonist of the transmembrane protein Smoothened in the Hedgehog
signaling pathway. It is indicated for the treatment of locally advanced basal cell carcinoma
(BCC) that is not amenable to curative ...
Nitrate and hormonal signaling crosstalk for plant growth and development
(2019)
Nitrate is an essential macronutrient for plants, a primary nitrogen source in natural and human-made ecosystems. Nitrate can also act as a signaling molecule that directs genome-wide gene expression changes with an impact ...