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Complex rearrangements are involved in Cephalanthera (Orchidaceae) chromosome evolution
(Springer Netherlands, 2007-12)
The genus Cephalanthera is an excellent plant group for karyotype evolution studies because it exhibits a dysploid series and bimodal karyotypes. With the aim of understanding their chromosomal and phylogenetic relationships, ...
Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
(Elsevier, 2012-03)
Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The ...
Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3
(Nature Publishing Group, 2017-01)
In previous studies using mice with macrophage-specific loss of TRPC3 we found a significant, selective effect of TRPC3 on the biology of M1, or inflammatory macrophages. Whereas activation of some components of the unfolded ...
Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line
(Elsevier, 2009-10)
Background: ATP exerts diverse effects on various cell types via speci fi c purinergic P2Y receptors. Intracellular signaling cascades are the main routes of communication between P2Y receptors and regulatory targets in ...
Thyroid hormone in the frontier of cell protection, survival and functional recovery
(Cambridge University Press, 2015)
Thyroid hormone (TH) exerts important actions on cellular energy metabolism, accelerating O-2
consumption with consequent reactive oxygen species (ROS) generation and redox signalling
affording cell protection, a response ...
Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease
(Associação Brasileira de Divulgação Científica, 2011)
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common human life-threatening monogenic disorders. The disease is characterized by bilateral, progressive renal cystogenesis and cyst and kidney ...
Altered expression of the costimulatory molecules CD80, CD86, CD152, PD-1 and ICOS on T-cells from paracoccidioidomycosis patients: Lack of correlation with T-cell hyporesponsiveness
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008)
T-cell proliferative hypo responsiveness, a hallmark of paracoccidioidomycosis immune responses, underlies host`s failure in controlling fungus spread, being reversible with antifungal treatment. The mechanisms leading to ...
IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice
(NATL ACAD SCIENCES, 2008)
IL-33, a new member of the IL-1 family, signals through its receptor ST2 and induces T helper 2 (Th2) cytokine synthesis and mediates inflammatory response. We have investigated the role of IL-33 in antigen-induced ...
Prognostic impact of adenomatous polyposis coil gene expression in osteosarcoma of the extremities
(ELSEVIER SCI LTD, 2010)
Purpose: To evaluate the impact of adjuvant chemotherapy on the outcome of osteosarcoma of the extremities, and to identify prognostic factors using the expression of adenomatous polyposis coli (APC), cadherin and beta-catenin ...
WNT-5A, but not matrix metalloproteinase 3 or beta-catenin protein, expression is related to early stages of lip carcinogenesis
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Background: Oncogenic Wnt/beta-catenin signaling occurs in numerous types of cancers, but little is known about the role of the Wnt protein family member, WNT-5A, in lip carcinogenesis. The aim of this study was to investigate ...