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Activación de STAT3 por hipoxia en modelos in vitro de cáncer de cuello uterino y en células endoteliales
(2017)
Introduction: The biological behavior of cancer cells is influenced by the tumor microenvironment in which they develop. In this context, stressor stimuli such as hypoxia are considered critical for tumor development and ...
Reactive oxygen species in cancer: A paradox between pro- and anti-tumour activities
(Springer, 2020-07)
Cancer constitutes a group of heterogeneous diseases that share common features. They involve the existence of altered cellular pathways which result in uncontrolled cell proliferation. Deregulation of production and/or ...
The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex: A Proteomic Analysis
(Wiley VCH Verlag, 2017-09)
Prenatal iron deficiency (pID) has been described to increase the risk for neurodevelopmental disorders such as autism and schizophrenia; however, the precise molecular mechanisms are still unknown. Here, we utilized high ...
Effects of let-7 microRNA on Cell Growth and Differentiation of Papillary Thyroid Cancer
(NEOPLASIA PRESS, 2009)
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy and RET/PTC rearrangements represent key genetic events frequently associated to this cancer, enhancing proliferation and dedifferentiation by ...
Efeitos do bisfenol A nas glândulas salivares de camundongos e em linhagem de células tumorais humanas.
(Universidade Federal de Minas GeraisBrasilFAO - FACULDADE DE ODONTOLOGIAPrograma de Pós-Graduação em OdontologiaUFMG, 2023-02-10)
Bisphenol A (BPA) is an endocrine-disrupting chemical with potential role in endocrine cancers. However, BPA effects on the salivary glands have been barely explored. We investigated the impact of in vivo sub-chronic ...
Nitrosative/Oxidative Stress Conditions Regulate Thioredoxin-Interacting Protein (TXNIP) Expression and Thioredoxin-1 (TRX-1) Nuclear Localization
(Public Library Science, 2013-12-20)
Thioredoxin (TRX-1) is a multifunctional protein that controls the redox status of other proteins. TRX-1 can be found in the extracellular milieu, cytoplasm and nucleus, and it has distinct functions in each environment. ...
Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression
(2021-02-01)
Cancer progression involves a variety of pro-tumorigenic biological processes including cell proliferation, migration, invasion, and survival. A cellular pathway implicated in these pro-tumorigenic processes is autophagy, ...
Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury
(2019-07-01)
Astrocytes are specialized cells capable of regulating inflammatory responses in neurodegenerative diseases or traumatic brain injury. In addition to playing an important role in neuroinflammation, these cells regulate ...
The Glucose-Related Decrease in Polar Auxin Transport During Ripening and its Possible Role in Grapevine Berry Coloring
(2023)
Auxin is a hormone that delays ripening in part by reducing anthocyanin content and impairing color development. Auxin content declines during the ripening process, whereas sugars accumulate from pre-veraison onwards. The ...
Apoptosis neuronal : la diversidad de señales y de tipos celulares.
(2012-04-23)
La muerte celular programada es un evento fisiológico durante el desarrollo. En el encéfalo y la médula espinal, este proceso
determina el número y la localización de los diferentes tipos celulares. En el sistema nervioso ...