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Mostrando ítems 4431-4440 de 9627
Dopamine Regulation of Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine
(Cell Press, 2016-06)
Striatal medium spiny neurons (MSNs) form inhibitory synapses on neighboring striatal neurons through axon collaterals. The functional relevance of this lateral inhibition and its regulation by dopamine remains elusive. ...
Myths and Facts on cytosolic sucrose hydrolysis
(Nova Science Publishers, 2013)
Sucrose plays an essential role in nature as part of the carbon dioxide assimilation pathway in the biosphere. Particularly, in plants occupies a unique position being essential for the allocation of carbon resources for ...
Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin, FAK, and Paxillin
(Elsevier Ireland, 2016-07-15)
Breast cancer is the most common malignancy in women, with metastases being the cause of death in 98%. In previous works we have demonstrated that retinoic acid (RA), the main retinoic acid receptor (RAR) ligand, is involved ...
Hyperosmolarity Impairs Human Extravillous Trophoblast Differentiation by Caveolae Internalization
(Frontiers Media, 2021-12)
We recently reported that an intact caveolar structure is necessary for adequate cell migration and tubulogenesis of the human extravillous trophoblast (EVT) cells. Emerging evidence supports that hyperosmolarity induces ...
Lithium therapy effects on the reproductive system
(Springer Nature Switzerland AG, 2018)
The chemical properties of lithium (Li) make it an extremely active substance in the body. It is active in the form of Li+ ion, so all salts have the same pharmacological action. Li salts are used to treat manic-depressive ...
MTORC2 controls actin polymerization required for consolidation of long-term memory
(Nature Publishing Group, 2013-04)
A major goal of biomedical research is the identification of molecular and cellular mechanisms that underlie memory storage. Here we report a previously unknown signaling pathway that is necessary for the conversion from ...
Effects of PPAR activation in the placenta and the fetus: implications in maternal diabetes
(Elsevier, 2011-03)
Peroxisome proliferator-activated receptors (PPARα, PPARδ and PPARγ) are ligand-activated transcription factors that regulate metabolic, anti-inflammatory and developmental processes. The maternal and fetal metabolic ...
A novel tilapia prolactin receptor is functionally distinct from its paralog
(Company of Biologists, 2009-06)
A novel tilapia prolactin (PRL) receptor (OmPRLR2) was identified based on its induction during hyperosmotic stress. OmPRLR2 protein shows 28% identity to tilapia OmPRLR1 and 26% identity to human PRLR. Comparison of OmPRLR1 ...
Insulin-like growth factor-I is a potential trophic factor for amacrine cells
(Wiley Blackwell Publishing, Inc, 2001-02)
In this study we show that insulin-like growth factor (IGF)-I selectively promotes survival and differentiation of amacrine neurons. In cultures lacking this factor, an initial degeneration pathway, selectively affecting ...
Participation of NADPH 4 oxidase in thyroid regulation
(Elsevier Ireland, 2019-01)
Different factors are involved in thyroid function and proliferation such as thyrotropin (TSH), insulin, growth factors, iodide, etc. TSH and IGF1/insulin increase proliferation rate and stimulate genes involved in thyroid ...