Buscar
Mostrando ítems 21-30 de 1447
Tankyrase inhibitors hinder Trypanosoma cruzi infection by altering host-cell signalling pathways
(Cambridge University Press, 2021-09)
Chagas disease is a potentially life-threatening protozoan infection affecting around 8 million people, for which only chemotherapies with limited efficacy and severe adverse secondary effects are available. The etiological ...
Phosphotyrosine phosphatases in cancer diagnostic and treatment
(Bentham Science Publishers, 2010-01)
The activation of proteins by post-translational modification represents an important cellular mechanism for regulating most aspects of biological organization and control, including growth, development, homeostasis, and ...
Immunohistochemical expression of selected phosphoproteins of the mTOR signalling pathway in canine cutaneous squamous cell carcinoma
(Elsevier, 2019-03)
Cutaneous squamous cell carcinoma (cSCC) represents one of the most common malignant skin tumors in dogs. Research aimed at clarifying how the deregulated activity of signalling pathways contributes to cSCC progression can ...
Signaling network involved in the GPC3-induced inhibition of breast cancer progression: role of canonical Wnt pathway
(Springer, 2018-09)
Purpose: We have shown that GPC3 overexpression in breast cancer cells inhibits in vivo tumor progression, by acting as a metastatic suppressor. GPC3-overexpressing cells are less clonogenic, viable and motile, while their ...
Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway
(Springer, 2015-10)
The pathogenesis of many viral infections lies on the damage caused by the immune response against the virus. Current antiviral drugs do not act on the inflammatory component of the disease. Thus, new compounds that inhibit ...
Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
(BioMed Central, 2011-10)
Background: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important ...
Alterations in the insulin signaling pathway in bovine ovaries with experimentally induced follicular persistence
(Elsevier Science Inc., 2020-12)
Reproductive diseases in dairy cows as cystic ovarian disease (COD) represent a major problem that impacts on dairy production. COD is characterized by anovulation, persistence of the dominant follicle, and interruption ...
cAMP-PKA signal transduction specificity in Saccharomyces cerevisiae
(Springer, 2020-09)
Living cells have developed a set of complex signaling responses, which allow them to withstand different environmental challenges. Signaling pathways enable the cell to monitor external and internal states and to articulate ...
Heme oxygenase activity and oxidative stress signalling in soybean leaves
(Elsevier Ireland, 2006-02)
We have previously demonstrated that the induction of heme oxygenase-1 (EC 1.14.99.3) plays a protective role for soybean plants against oxidative stress. Here, we have investigated for the first time the possible signal ...