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Absence of IFN gamma expression induces neuronal degeneration in the spinal cord of adult mice
(Biomed Central LtdLondonInglaterra, 2010)
Triheptanoin protects against status epilepticus induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration
(Wiley, 2018)
Triheptanoin, the triglyceride of heptanoate, is anaplerotic (refills deficient tricarboxylic acid cycle intermediates) via the propionyl-CoA carboxylase pathway. It has been shown to be neuroprotective and anticonvulsant ...
Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
(Medknow Publications, 2020-05)
The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events. Early in the neurodegenerative process, glial cells ...
Parkinson’s disease: A review from pathophysiology to treatment
(2020-01-01)
Parkinson's Disease (PD) is the second most common neurodegenerative disease in the elderly population, with a higher prevalence in men, independent of race and social class; it affects approximately 1.5 to 2.0% of the ...
ENA/VASP downregulation triggers cell death by impairing axonal maintenance in hippocampal neurons
(Elsevier, 2010-04)
Neurodegenerative diseases encompass a broad variety of motor and cognitive disorders that are accompanied by death of specific neuronal populations or brain regions. Cellular and molecular mechanisms underlying these ...
Iron mediates neuritic tree collapse in mesencephalic neurons treated with 1-methyl-4-phenylpyridinium (MPP+)
(Springer, 2011)
Studies in post-mortem tissues of patients with
Parkinson’s disease (PD) and in mice treated with 6-hydroxydopamine
have shown a decrease in the length of
axon and dendrites of striatal neurons. However, the etiology
of ...
Axonal Degeneration Is Mediated by Necroptosis Activation
(2019)
Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated ...
Increased sensory neuron apoptotic death 2 weeks after peripheral axotomy in C57BL/6J mice compared to A/J mice
(Elsevier Ireland LtdClareIrlanda, 2006)