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Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models
(2014-02-20)
Abstract
Background
SET/I2PP2A is a multifunctional protein that is up-regulated in head and neck squamous cell carcinoma (HNSCC). The action of SET in HNSCC tumorigenicity ...
Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models
(BMC, 2014-02-20)
Background
SET/I2PP2A is a multifunctional protein that is up-regulated in head and neck squamous cell carcinoma (HNSCC). The action of SET in HNSCC tumorigenicity is unknown.
...
Human umbilical cord perivascular cells exhibit enhanced cardiomyocyte reprogramming and cardiac function after experimental acute myocardial infarction
(Sage Publications, 2013-09)
We were interested in evaluating the ability of the mesenchymal stromal cell (MSC) population, human umbilical cord perivascular cells (HUCPVCs), to undergo cardiomyocyte reprogramming in an established co-culture system ...
Influência do número de cópias do gene para a ECA sobre componentes do Sistema Renina-Angiotensina e marcadores de hipertrofia cardíaca em camundongos diabéticos
(Universidade Federal de São Paulo (UNIFESP), 2015-10-31)
Com o crescimento exponencial do diabetes melito (DM) nas últimas décadas, muita atenção tem sido direcionada às morbidades decorrentes desta doença, como a cardiomiopatia diabética, associada a alterações moleculares, de ...
Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy
(BMC, 2021)
Background Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that ...
Análisis de la pérdida de textura de la carne de Yamú (Brycon amazonicus) por efecto de la congelación
(2016-04-21)
El propósito de este trabajo consistió en evaluar el efecto de la conservación en frío sobre la carne del pescado Yamú (Brycon amazonicus), utilizando un diseño factorial 2 X 2 X 3; utilizando dos temperaturas diferentes ...
Antigen-based nano-immunotherapy controls parasite persistence, inflammatory and oxidative stress, and cardiac fibrosis, the hallmarks of chronic chagas cardiomyopathy, in a mouse model of trypanosoma cruzi infection
(Multidisciplinary Digital Publishing Institute, 2020-02-21)
Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts. In this study, we cloned TcG2 ...
Cardiac Thyrotropin-releasing Hormone Inhibition Improves Ventricular Function and Reduces Hypertrophy and Fibrosis After Myocardial Infarction in Rats
(Churchill Livingstone Inc Medical Publishers, 2021-07)
Background: Cardiac thyrotropin-releasing hormone (TRH) is a tripeptide with still unknown functions. We demonstrated that the left ventricle (LV) TRH system is hyperactivated in spontaneously hypertensive rats and its ...
Alterações estruturais e perfil da expressão gênica durante o desenvolvimento muscular esquelético pós-natal em suínos de diferentes pesos ao nascimento
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2017-05-05)
Low birth weight piglets have compromised postnatal growth due to impaired muscle
accretion, which may affect meat quality in these animals. The present study investigated
skeletal muscle development in different birth ...
Alterações neuromusculares em modelos animais de disfunção colinérgica e sua relação com as Síndromes Miastênicas Congênitas
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MORFOLOGIAPrograma de Pós-Graduação em Biologia CelularUFMG, 2018-04-26)
In mammals, muscle activity is dependent on acetylcholine (ACh) release from neuromuscular junctions (NMJs), and changes with the cholinergic neurotransmission are associated with a variety of neuromuscular disorders, ...