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Chronic Stress and Glucocorticoid Receptor Resistance in Asthma
(Elsevier, 2020-06)
Purpose: Chronic and persistent exposure to negative stress can lead to adverse consequences on health. Particularly, psychosocial factors were found to increase the risk and outcome of respiratory diseases like asthma. ...
MKK3/6-p38 MAPK signaling is required for IL-1 beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells
(Mary Ann Liebert, Inc., 2006-10-01)
Coupled bone turnover is directed by the expression of receptor-activated NF-kappa B ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG). Proinflammatory cytokines, such as interleukin-1 beta (IL-1 beta) and tumor ...
MKK3/6-p38 MAPK signaling is required for IL-1 beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells
(Mary Ann Liebert, Inc., 2006-10-01)
Coupled bone turnover is directed by the expression of receptor-activated NF-kappa B ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG). Proinflammatory cytokines, such as interleukin-1 beta (IL-1 beta) and tumor ...
Caracterização biofísico-química das proteínas FGFR2 e Grb2 e sua dinâmica de interação
(Universidade Estadual Paulista (Unesp), 2019-04-23)
FGFR2 (Fibroblast Growth Factor Receptor 2) é uma proteína receptora que apresenta um papel crucial na regulação do metabolismo celular, expressão gênica, crescimento, divisão e diferenciação celular. Vias de sinalização ...
The cardiofaciocutaneous syndrome
(B M J Publishing Group, 2006-11-01)
The cardiofaciocutaneous (CFC) syndrome is a condition of sporadic occurrence, with patients showing multiple congenital anomalies and mental retardation. It is characterised by failure to thrive, relative macrocephaly, a ...
Heat-stress triggers MAPK crosstalk to turn on the hyperosmotic response pathway
(Nature Publishing Group, 2018-12)
Cells make decisions based on a combination of external and internal signals. In yeast, the high osmolarity response (HOG) is a mitogen-activated protein kinase (MAPK) pathway that responds to a variety of stimuli, and it ...