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Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss
(2010)
Alveolar bone loss associated with periodontal diseases is the result of osteoclastogenesis induced by bacterial pathogens. The mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a critical negative regulator ...
Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1 beta, IL-6 and IL-10 on human macrophages
(Springer, 2014-09-01)
Tea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its components (terpinen-4-ol and ...
Rac1 modulates TGF-b1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes
(ELSEVIER, 2010)
Transforming growth factor-b1 (TGF-b1) activates Rac1 GTPase in mouse transformed keratinocytes.
Expression of a constitutively active Q61LRac1 mutant induced an epithelial to mesenchymal transition
(EMT) linked to ...
Immune-expression of HSP27 and IL-10 in recurrent aphthous ulceration
(Wiley-Blackwell, 2008-09-01)
BACKGROUND: Recently, abnormal cellular immune response has been considered responsible for the oral lesion in the recurrent aphthous ulceration (RAU). for reasons not yet defined, antigens of the oral microbiota would ...
Signaling Pathways Activation by Primary Endodontic Infectious Contents and Production of Inflammatory Mediators
(Elsevier B.V., 2014-04-01)
Introduction: This study investigated the bacterial community involved in primary endodontic diseases, evaluated its ability to activate the macrophage Toll-like receptor 4 receptor through p38 mitogen-activated protein ...