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Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
(Frontiers, 2014-06)
The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output ...
Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy
(Elsevier, 2015)
Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and
encompasses structural, morphological, functional, and metabolic abnormalities in the heart.Myocardial energy
metabolism ...
Ceramide-induced BOK promotes mitochondrial fission in preeclampsia
(2018-03-01)
Mitochondria are in a constant balance of fusing and dividing in response to cellular cues. Fusion creates healthy mitochondria, whereas fission results in removal of non-functional organelles. Changes in mitochondrial ...
Nanotechnology-based drug delivery strategies to repair the mitochondrial function in neuroinflammatory and neurodegenerative diseases
(MDPI, 2021)
Mitochondria are vital organelles in eukaryotic cells that control diverse physiological processes related to energy production, calcium homeostasis, the generation of reactive oxygen species, and cell death. Several studies ...
Deregulation of Mitochondria-Shaping Proteins Opa-1 and Drp-1 Plays a Decisive Role in Manganese-Induced Apoptosis
(Public Library Of Science, 2014-03)
Mitochondria are dynamic organelles that undergo fusion and fission processes. These events are regulated by mitochondria-shaping proteins. Changes in the expression and/or localization of these proteins lead to a ...
Polycystin-1 regulates cardiomyocyte mitophagy
(Wiley, 2021)
Polycystin-1
(PC1) is a transmembrane protein found in different cell types, including
cardiomyocytes. Alterations in PC1 expression have been linked to mitochondrial
damage in renal tubule cells and in patients with ...
Cardiac-specific overexpression of thioredoxin 1 attenuates mitochondrial and myocardial dysfunction in septic mice
(Pergamon-Elsevier Science Ltd, 2016-12)
Sepsis-induced myocardial dysfunction is associated with increased oxidative stress and mitochondrial dysfunction. Current evidence suggests a protective role of thioredoxin-1 (Trx1) in the pathogenesis of cardiovascular ...
Subcellular structure of prenatal human ovary: Mitochondrial distribution during meiotic prophase
(1990)
The dynamics of mitochondrial population during the first meiotic prophase in the fetal human ovary was studied in sequential stages of development, from week 13 to week 23 of intrauterine life; the study was performed by ...
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
(ELSEVIER SCIENCE BV, 2008-01-15)
Aims In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...