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The shape of mitochondrial dysfunction in Down Syndrome
(John Wiley & Sons Inc, 2019-07)
Oxidative stress (OS) and mitochondrial dysfunction (MD) have been extensively studied and defined as therapeutic targets in Down syndrome (DS). Though originally associated to individual genes located in supernumerary ...
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitocondrial fission and stimulates mitocondrial Ca2+ uptake inprimary hippocampal neurons
(2014)
Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+ signals and promotes ...
Inhibition of mitochondrial fission by Drp-1 blockade by short-term leptin and Mdivi-1 treatment improves white adipose tissue abnormalities in obesity and diabetes
(Academic Press Ltd - Elsevier Science Ltd, 2021-12-06)
Background: Obesity and type 2 diabetes are chronic diseases characterized by insulin resistance, mitochondrial dysfunction and morphological abnormalities. Objective: We have investigated if dysregulation of mitochondrial ...
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
(2008)
AIMS: In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
Ryanodine receptor-mediated ca2+ release underlies iron-induced mitochondrial fission and stimulates nnitochondrial ca2+ uptake in primary hippocampal neurons
(FRONTIERS RESEARCH FOUNDATION, 2014)
Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+ signals and promotes ...
Effect of moderate exercise on skeletal muscle mitochondrial function and dynamics in obese Zucker rats
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-06)
Obesity and metabolic syndrome are related to a significant reduction in mitochondrial quality. Current evidence suggests that both conditions promote an unbalance between fusion and fission, the main events of mitochondrial ...