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Mostrando ítems 1241-1250 de 1973
IGF-1R Regulates the extracellular level of active MMP-2, pathological neovascularization and functionality in retinas of OIR mouse model
(Humana Press, 2017-01)
In ischemic proliferative diseases such as retinopathies, persistent hypoxia leads to the release of numerous neovascular factors that participate in the formation of abnormal vessels and eventually cause blindness. The ...
Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
(Wiley Blackwell Publishing, Inc, 2017-04)
Problem: Multiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that ...
Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
(Bentham Science Publishers, 2011-04)
Matrix metalloproteinases (MMPs) have been implicated in both normal and pathologic processes. In cancer in particular, in vitro and animal studies showed an involvement of MMPs in many stages of cancer progression. This ...
Gels Containing MMP Inhibitors Prevent Dental Erosion in situ
(SAGE PUBLICATIONS INC, 2010)
Matrix metalloproteinase (MMP) inhibition has been shown to reduce dentin caries progression, but its role in dental erosion has not yet been assessed. This study tested the hypothesis that gels containing MMP inhibitors ...
Ethanol Wet-bonding Challenges Current Anti-degradation Strategy
(SAGE PUBLICATIONS INC, 2010)
The long-term effectiveness of chlorhexidine as a matrix metalloproteinase (MMP) inhibitor may be compromised when water is incompletely removed during dentin bonding. This study challenged this anti-bond degradation ...
Activatión of pro-inflammatory functións in bovine neutrophils by store operated calcium entry (soce)
(2011)
Neutrophilic infiltration is an early process in acute inflammation. Pro-inflammatory functions in neutrophils, as in other non-excitable cells, is regulated by intracellular calcium concentrations [ Ca2+] i. One of the ...
Preeclampsia associates with RECK-dependent decrease in human trophoblasts migration and invasion
(2017)
Introduction: Preeclampsia is characterized by reduced invasion capacity of trophoblasts involving lower matrix metalloproteinase (MMP) activity. Cell invasion is reduced by reversion-inducing-cysteine-rich protein with ...
Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils
(2016)
Fatty acids have been recognized as regulators of immune function in addition to their known metabolic role. Long-chain fatty acids bind free fatty acid receptor (FFAR)-1/GPR40, which is expressed on bovine neutrophils, ...
Docosahexaenoic acid and TUG-891 activate free fatty acid-4 receptor in bovine neutrophils
(2019)
Fatty acids are well known metabolic intermediaries but also have a role in the immune response. Long-chain fatty acids such as omega-6 and -9 activate neutrophil function through free fatty acid (FFA)-1 receptor in bovines. ...
Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis
(2015)
BackgroundTherapeutic options to treat Non-alcoholic steatohepatitis (NASH) are limited. Mineralocorticoid receptor (MR) activation could play a role in hepatic fibrogenesis and its modulation could be beneficial for NASH. ...